Non-enveloped virus membrane penetration: New advances leading to new insights.
Non-enveloped virus membrane penetration: New advances leading to new insights.
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DOI：
10.1371/journal.ppat.1010948
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发表时间：
2022-12
期刊：
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
宿主细胞膜对无包膜病毒提出了特别的挑战。有包膜病毒通过脂质包膜与细胞膜融合进入细胞，而无包膜病毒通常必须（1）通过内吞作用进入细胞，然后（2）穿透细胞内膜到达细胞质。只有这样，病毒才能开始复制（或转移到细胞核进行复制）。尽管无包膜病毒的膜穿透是关键的进入步骤，但该过程的许多精确分子细节仍不清楚。最近的研究结果已经开始解开各种机制，其中无包膜病毒蛋白破坏和渗透细胞内膜。具体而言，高分辨率显微镜研究揭示了病毒蛋白质的精确构象变化，使渗透，而生化研究已经确定了关键的宿主蛋白质，促进病毒的渗透和运输。这篇简短的文章总结了三种研究最深入的无包膜病毒家族在膜穿透过程中的新发现：呼肠孤病毒，乳头瘤病毒和多瘤病毒。
Host cell membranes pose a particular challenge for non-enveloped viruses. Whereas enveloped viruses enter cells by fusing their lipid envelopes with the cellular membrane, non-enveloped viruses generally must (1) enter cells via endocytosis, then (2) penetrate the cellular endomembrane to reach the cytosol. Only then can the viruses begin to replicate (or transit to the nucleus to replicate). Although membrane penetration of non-enveloped viruses is a crucial entry step, many of the precise molecular details of this process remain unclear. Recent findings have begun to untangle the various mechanisms by which non-enveloped viral proteins disrupt and penetrate cellular endomembranes. Specifically, high-resolution microscopy studies have revealed precise conformational changes in viral proteins that enable penetration, while biochemical studies have identified key host proteins that promote viral penetration and transport. This brief article summarizes new discoveries in the membrane penetration process for three of the most intensely studied families of non-enveloped viruses: reoviruses, papillomaviruses, and polyomaviruses.
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影响因子：
28.3
作者：
通讯作者：
--
影响因子：
6.7
作者：
Harwood MC;Dupzyk AJ;Inoue T;DiMaio D;Tsai B
通讯作者：
Tsai B
影响因子：
64.8
作者：
LIDDINGTON, RC;YAN, Y;HARRISON, SC
通讯作者：
HARRISON, SC
DOI：
10.1073/pnas.1423026112
发表时间：
2015-01-13
影响因子：
11.1
作者：
Chen, Shuliang;Desai, Tanvi;Novick, Peter J.
通讯作者：
Novick, Peter J.
影响因子：
21.3
作者：
Geiger, Roger;Andritschke, Daniel;Helenius, Ari
通讯作者：
Helenius, Ari