Regional cerebral function determined by FDG-PET in healthy volunteers: normal patterns and changes with age.
Regional cerebral function determined by FDG-PET in healthy volunteers: normal patterns and changes with age.
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发表时间：
1995-07
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通讯作者：
A. Loessner;A. Alavi;K. Lewandrowski;D. Mozley;E. Souder;R. Gur
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作者：
A. Loessner;A. Alavi;K. Lewandrowski;D. Mozley;E. Souder;R. Gur
本研究的主要目的是利用高分辨率PET确定正常健康志愿者的区域脑代谢活动模式和不同年龄组的变化。方法120例健康正常志愿者（男性64例，女性56例），年龄19 ~ 79岁，获得全脑高分辨率[18F]FDG PET图像。采用定性评分量表对各解剖区域进行评分，评分范围为1 ~ 6（1 =绝对正常，6 =绝对异常）。与正常(0)状态相比，局部代谢活性也显示出增加（+）或减少（-）。结果在正常衰老中最一致的发现是皮层代谢下降，尤其是额叶。颞叶、顶叶和枕叶的代谢在同一年龄组和几十年内的受试者之间有很大的差异。基底节区、海马区、丘脑、小脑、扣带后回和视觉皮层的代谢随年龄增长而保持不变。这些数据表明，FDG-PET图像的定性解释可以准确评估正常受试者的大脑区域代谢活动，类似于定量技术。充分了解与正常衰老相关的正常变异和变化是对病理状态进行最佳评估的必要条件。
UNLABELLED The main objective of this study was to determine patterns of regional brain metabolic activity utilizing high-resolution PET in normal healthy volunteers and variations in different age groups. METHODS High-resolution [18F]FDG PET images of the entire brain were obtained in 120 healthy normal volunteers (64 men, 56 women), age range from 19 to 79 yr. Each anatomic region was assessed using a qualitative rating scale with a score ranging from 1 to 6 (1 = definitely normal and 6 = definitely abnormal). Local metabolic activity was also estimated as showing increased (+) or decreased (-) compared to normal (0) states. RESULTS The most consistent finding in normal aging was decreased cortical metabolism, particularly in the frontal lobes. Temporal, parietal and occipital lobe metabolism varied considerably among subjects within the same age group as well as over decades. Basal ganglia, hippocampal area, thalami, cerebellum, posterior cingulate gyrus and visual cortex remained metabolically unchanged with advancing age. CONCLUSION These data indicate that qualitative interpretation of FDG-PET images allows accurate assessment of regional metabolic activity of the brain in normal subjects similar to those described with quantitative techniques. Adequate knowledge of normal variations and changes related to normal aging is necessary for optimal assessment of pathologic states.