Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women
Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women
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DOI：
10.1007/s00432-004-0663-7
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发表时间：
2005-07-01
影响因子：
3.6
通讯作者：
Wingren, S
中科院分区：
文献类型：
--
作者：
Bergman, M;Ahnström, M;Wingren, S
目的：锰超氧化物歧化酶（MnSOD）是参与细胞防御活性氧的主要酶之一。在不同的癌组织中观察到MnSOD的低表达，并且一些报道表明MnSOD的过表达抑制各种人类癌细胞的生长。这些观察结果表明，MnSOD参与致癌作用。MnSOD基因的线粒体靶向序列（MTS）中的多态性（Ala-9Val）已被提出影响蛋白质定位，从而影响细胞对超氧自由基的防御。方法：采用病例对照研究，对118例早发乳腺癌患者（
Purpose: Manganese superoxide dismutase (MnSOD) is one of the major enzymes implicated in the cellular defence against reactive oxygen species. Low expression of MnSOD has been observed in different cancer tissues and several reports have shown that overexpression of MnSOD inhibits growth in various human cancer cells. These observations suggest that MnSOD is involved in carcinogenesis. A polymorphism (Ala-9Val) in the mitochondrial targeting sequence (MTS) of the MnSOD gene has been proposed to affect protein localization and thereby influence cellular defence against superoxide radicals. Methods: In the present case-control study, including 118 early onset breast cancer patients (