Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene
Hunger Potentiates the Habenular Winner Pathway for Social Conflict by Orexin-Promoted Biased Alternative Splicing of the AMPA Receptor Gene
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DOI：
10.1016/j.celrep.2020.107790
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发表时间：
2020-06-23
期刊：
影响因子：
8.8
通讯作者：
Okamoto, Hitoshi
中科院分区：
文献类型：
--
作者：
Nakajo, Haruna;Chou, Ming-Yi;Okamoto, Hitoshi
许多动物在同类之间为争夺统治地位而争斗。由于胜利者可以获得比失败者更多的资源，战斗的结果对动物的生存很重要，特别是在资源不足的情况下，如饥饿。然而，饥饿是否以及如何影响战斗结果仍不清楚。在此，我们研究了食物剥夺对斑马鱼大脑活动和战斗行为的影响，我们报告了饥饿诱导在社会冲突中获胜。在战斗之前，饥饿的鱼表现出增强的外侧亚区的背侧缰（dHbL）-背侧/中间脚间核（d/iIPN）的途径，这是必不可少的，并增强后赢得战斗。回路增强由下丘脑食欲素/下丘脑泌素神经肽介导，其通过增加AMPA型谷氨酸受体（AMPAR）亚基的选择性剪接变体的翻转类型的表达来延长AMPA型谷氨酸受体（AMPAR）活性。这种机制可能是饥饿的脊椎动物如何赢得战斗的基础，并且可能在动物的生殖过程中普遍存在。
Many animals fight for dominance between conspecifics. Because winners could obtain more resources than losers, fighting outcomes are important for the animal's survival, especially in a situation with insufficient resources, such as hunger. However, it remains unclear whether and how hunger affects fighting outcomes. Herein, we investigate the effects of food deprivation on brain activity and fighting behaviors in zebrafish, We report that starvation induces winning in social conflicts. Before the fights, starved fish show potentiation of the lateral subregion of the dorsal habenula (dHbL)-dorsal/intermediate interpeduncular nucleus (d/iIPN) pathway, which is known to be essential for and potentiated after winning fights. Circuit potentiation is mediated by hypothalamic orexin/hypocretin neuropeptides, which prolong AMPA-type glutamate receptor (AMPAR) activity by increasing the expression of a flip type of alternative splicing variant of the AMPAR subunit. This mechanism may underlie how hungry vertebrates win fights and may be commonly shared across animal phylogeny.