Beyond tissue concentrations: antifungal penetration at the site of infection.
Beyond tissue concentrations: antifungal penetration at the site of infection.
复制标题
超越组织浓度：感染部位的抗真菌渗透。
DOI：
10.1093/mmy/myy067
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发表时间：
2019
期刊：
影响因子：
2.9
通讯作者：
Perlin,DavidS
中科院分区：
文献类型：
--
作者：
Zhao,Yanan;Prideaux,Brendan;Baistrocchi,Shane;Sheppard,DonaldC;Perlin,DavidS
尽管抗真菌治疗取得了进展，侵袭性真菌感染仍然是世界范围内发病率和死亡率的重要原因。导致现有抗真菌药物相对无效的一个重要因素是感染部位的药物暴露不足。尽管抗真菌治疗在这方面很重要，但我们通常缺乏对抗真菌药物在不同组织亚室中如何分布、渗透和与靶生物相互作用的充分认识。更好地了解药物分布对于指导适当使用现有的抗真菌药物以及帮助开发新药物至关重要。在此，我们简要回顾了目前抗真菌药物在感染部位暴露的观点，并描述了一种新技术，基质辅助激光解吸电离（MALDI）质谱成像，它有可能极大地扩展我们对药物渗透的理解。
Despite advances in antifungal therapy, invasive fungal infections remain a significant cause of morbidity and mortality worldwide. One important factor contributing to the relative ineffectiveness of existing antifungal drugs is insufficient drug exposure at the site of infection. Despite the importance of this aspect of antifungal therapy, we generally lack a full appreciation of how antifungal drugs distribute, penetrate, and interact with their target organisms in different tissue subcompartments. A better understanding of drug distribution will be critical to guide appropriate use of currently available antifungal drugs, as well as to aid development of new agents. Herein we briefly review current perspectives of antifungal drug exposure at the site of infection and describe a new technique, matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging, which has the potential to greatly expand our understanding of drug penetration.