Genetically engineered mice as experimental tools to dissect the critical events in breast cancer.
Genetically engineered mice as experimental tools to dissect the critical events in breast cancer.
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DOI：
10.1016/b978-0-12-800249-0.00008-1
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发表时间：
2014
影响因子：
--
通讯作者：
Fisher, Paul B.
中科院分区：
文献类型：
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作者：
Menezes, Mitchell E.;Das, Swadesh K.;Emdad, Luni;Windle, Jolene J.;Wang, Xiang-Yang;Sarkar, Devanand;Fisher, Paul B.
基因工程小鼠模型和异种移植技术的突破性进展极大地促进了乳腺癌发病机制的研究。目前可用的大量乳腺癌小鼠模型证明了乳腺肿瘤发生的复杂性，以及研究人员试图准确描绘这种疾病的异质性和复杂性。不同的分子变化，驱动肿瘤发生的各个方面，如肿瘤细胞增殖和凋亡，侵袭和转移，血管生成和耐药性的改变已被评估使用目前可用的GEM乳腺癌模型。GEM乳腺癌模型也被用来评估和验证新的治疗方法，疫苗和成像模式的有效性，以供临床使用。本文综述了各种GEM模型的概要，这些模型正在扩大我们对乳腺癌发展和进展的细微差别的认识，并有助于开发这种疾病的新预防和治疗方法。
Elucidating the mechanism of pathogenesis of breast cancer has greatly benefited from breakthrough advances in both genetically engineered mouse (GEM) models and xenograft transplantation technologies. The vast array of breast cancer mouse models currently available is testimony to the complexity of mammary tumorigenesis and attempts by investigators to accurately portray the heterogeneity and intricacies of this disease. Distinct molecular changes that drive various aspects of tumorigenesis, such as alterations in tumor cell proliferation and apoptosis, invasion and metastasis, angiogenesis, and drug resistance have been evaluated using the currently available GEM breast cancer models. GEM breast cancer models are also being exploited to evaluate and validate the efficacy of novel therapeutics, vaccines, and imaging modalities for potential use in the clinic. This review provides a synopsis of the various GEM models that are expanding our knowledge of the nuances of breast cancer development and progression and can be instrumental in the development of novel prevention and therapeutic approaches for this disease.