Programmable Hydrogel Ionic Circuits for Biologically Matched Electronic Interfaces
Programmable Hydrogel Ionic Circuits for Biologically Matched Electronic Interfaces
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DOI：
10.1002/adma.201800598
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发表时间：
2018-06
影响因子：
29.4
通讯作者：
Siwei Zhao;P. Tseng;J. Grasman;Yu Wang;Wenyi Li;Bradley Napier;B. Yavuz;Ying Chen;Laurel Howell-Lau
中科院分区：
文献类型：
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作者：
Siwei Zhao;P. Tseng;J. Grasman;Yu Wang;Wenyi Li;Bradley Napier;B. Yavuz;Ying Chen;Laurel Howell-Lau
对可穿戴和可植入医疗设备的需求不断增加，推动了对与生活系统接口的电子设备的需求。目前的生物电子系统还没有完全解决工程电路和生物系统之间的不匹配，包括由此产生的疼痛和对生物组织的损害。在这里，盐/聚乙二醇双水相体系被用来产生可编程水凝胶离子电路。高电导率盐溶液图案通过盐/聚乙二醇相分离稳定地包裹在聚乙二醇水凝胶基质中，以高分辨率传递离子电流，并实现局部电刺激。这一策略允许设计者设计与生物系统匹配的电子产品，包括透明度、可伸缩性、完整的水基连接界面、在工程系统和生物系统之间分发离子电信号，以及避免电刺激对组织的损害。这种系统的潜力通过产生基于发光二极管(LED)的显示器、皮肤贴装电子设备和刺激器来展示，这些刺激器将局部电流传递到体外神经元培养和体内肌肉，并减少不良影响。这样的电子平台可能构成未来生物集成电子系统的基础。
The increased need for wearable and implantable medical devices has driven the demand for electronics that interface with living systems. Current bioelectronic systems have not fully resolved mismatches between engineered circuits and biological systems, including the resulting pain and damage to biological tissues. Here, salt/poly(ethylene glycol) (PEG) aqueous two‐phase systems are utilized to generate programmable hydrogel ionic circuits. High‐conductivity salt‐solution patterns are stably encapsulated within PEG hydrogel matrices using salt/PEG phase separation, which route ionic current with high resolution and enable localized delivery of electrical stimulation. This strategy allows designer electronics that match biological systems, including transparency, stretchability, complete aqueous‐based connective interface, distribution of ionic electrical signals between engineered and biological systems, and avoidance of tissue damage from electrical stimulation. The potential of such systems is demonstrated by generating light‐emitting diode (LED)‐based displays, skin‐mounted electronics, and stimulators that deliver localized current to in vitro neuron cultures and muscles in vivo with reduced adverse effects. Such electronic platforms may form the basis of future biointegrated electronic systems.