Effects of bed nucleus of the stria terminalis lesions on conditioned anxiety: Aversive conditioning with long-duration conditional stimuli and reinstatement of extinguished fear
Effects of bed nucleus of the stria terminalis lesions on conditioned anxiety: Aversive conditioning with long-duration conditional stimuli and reinstatement of extinguished fear
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DOI：
10.1037/0735-7044.120.2.324
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发表时间：
2006-04-01
影响因子：
1.9
通讯作者：
Bouton, ME
中科院分区：
文献类型：
--
作者：
Waddell, J;Morris, RW;Bouton, ME
四个实验研究了终纹床核（BLAST）病变对条件性恐惧和焦虑的影响。虽然BLAST病变没有破坏恐惧条件与短期条件刺激（CS;实验1和3），病变衰减条件与较长的持续时间CS（实验1和2）。实验3发现，病变衰减恢复熄灭的恐惧，这依赖于上下文条件反射。实验4证实，在高架零迷宫的损伤减少非条件性焦虑。作者认为，长持续时间的CS，无论是明确的线索或上下文，引起焦虑的条件反应，这是分离的恐惧反应较短的CS。结果是一致的恐惧和焦虑之间的行为和解剖学的区别，并与防御条件反射的行为系统的观点。
Four experiments investigated the effects of lesions of the bed nucleus of the stria terminalis (BLAST) on conditioned fear and anxiety. Though BLAST lesions did not disrupt fear conditioning with a short-duration conditional stimulus (CS; Experiments 1 and 3), the lesion attenuated conditioning with a longer duration CS (Experiments 1 and 2). Experiment 3 found that lesions attenuated reinstatement of extinguished fear, which relies on contextual conditioning. Experiment 4 confirmed that the lesion reduced unconditioned anxiety in an elevated zero maze. The authors suggest that long-duration CSs, whether explicit cues or contexts, evoke anxiety conditioned responses, which are dissociable from fear responses to shorter CSs. Results are consistent with behavioral and anatomical distinctions between fear and anxiety and with a behavior-systems view of defensive conditioning.