Serum levels of vascular endothelial growth factor in patients with acute myocardial infarction undergoing reperfusion therapy
Serum levels of vascular endothelial growth factor in patients with acute myocardial infarction undergoing reperfusion therapy
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DOI：
10.1042/cs0920453
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发表时间：
1997-05-01
期刊：
影响因子：
6
通讯作者：
Yazaki, Y
中科院分区：
文献类型：
--
作者：
Seko, Y;Imai, Y;Yazaki, Y
1.血管内皮生长因子是一种有效的促血管生成的有丝分裂原，已知其在局部缺血时被诱导并由肿瘤细胞分泌。然而，急性心肌梗死时血管内皮生长因子释放的确切机制以及冠状动脉再灌注对循环中血管内皮生长因子水平的影响尚不清楚.对19例急性心肌梗死患者进行了早期再灌注治疗。与19名健康对照受试者相比，再灌注前血清血管内皮生长因子水平显著升高[252.4 ± 158.1 pg/ml（平均值± SD）与未检测到相比]。再灌注后，血清血管内皮生长因子水平迅速恢复，几乎完全恢复到正常对照范围.这些数据有力地表明，血清血管内皮生长因子水平是心肌缺血最敏感的指标之一。
1. Vascular endothelial growth factor, a potent angiogenic mitogen, is known to be induced in response to ischaemia as well as being secreted from tumour cells. However, the precise mechanism of vascular endothelial growth factor release in acute myocardial infarction and the effects of coronary reperfusion on the circulating levels of vascular endothelial growth factor are still unknown.2. Nineteen patients with acute myocardial infarction who underwent early reperfusion therapy were studied. Serum levels of vascular endothelial growth factor before reperfusion were markedly increased as compared with those in 19 healthy control subjects [252.4 +/- 158.1 pg/ml (mean +/- SD) compared with undetectable]. After reperfusion, the serum vascular endothelial growth factor levels rapidly returned almost completely to the normal control range.4. These data strongly suggest that the serum level of vascular endothelial growth factor is one of the most sensitive indicators of myocardial ischaemia.