Virus-host interactions and the pathogenesis of murine and human oncogenic retroviruses.
Virus-host interactions and the pathogenesis of murine and human oncogenic retroviruses.
复制标题
病毒与宿主的相互作用以及鼠和人类致癌逆转录病毒的发病机制。
DOI：
10.1007/978-3-642-76524-7_5
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发表时间：
1991
影响因子：
--
通讯作者：
Lazo,PA
中科院分区：
文献类型：
--
作者：
Tsichlis,PN;Lazo,PA
逆转录病毒是一组异质的正链RNA病毒，其通过DNA中间体复制其RNA基因组。在其生命周期中，逆转录病毒以多种方式与宿主相互作用。因此，病毒基因产物与细胞蛋白质相互作用并调节或破坏它们的功能。此外，前病毒DNA整合到细胞基因组中，引入改变感染细胞生物学的突变。病毒和宿主之间的这些相互作用以及与之相关的现象决定了逆转录病毒的致病性（Lazoand Tsichlis 1990和本卷）。
Retroviruses are a heterogeneous group of plus strand RNA viruses which replicate their RNA genome through a DNA intermediate. During their life cycle the retroviruses interact with the host in a variety of ways. Thus, viral gene products interact with cellular proteins and modulate or subvert their function. Furthermore, the proviral DNA integrates into the cellular genome introducing mutations which alter the biology of the infected cell. These interactions between the virus and the host and the phenomena associated with them determine the pathogenicity of retroviruses (Lazoand Tsichlis1990 and this volume).