Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release
Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release
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DOI：
10.1039/c2cc32373g
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
You, Youngjae
中科院分区：
文献类型：
--
作者：
Bio, Moses;Nkepang, Gregory;You, Youngjae
提出了一种新的光不稳定连接体--氨基丙烯酸酯的“点击和光去点击化学”。加合物在2个步骤中以良好的产率构建，并通过具有光敏剂的组织可穿透的可见光（690 nm）快速裂解。证明了母体药物的容易合成、释放以及在介质中的稳定性和裂解。
"Click and Photo-unclick Chemistry'' of aminoacrylates is proposed for a new photo-labile linker. Adducts are built in 2 steps with good yields and cleaved rapidly by tissue penetrable visible light (690 nm) with a photosensitizer. Facile synthesis, release of mother drug, and stability and cleavage in medium are demonstrated.