A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
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DOI：
10.1016/s0092-8674(00)80853-3
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发表时间：
2000-05-12
期刊：
影响因子：
64.5
通讯作者：
Ericson, J
中科院分区：
文献类型：
--
作者：
Briscoe, J;Pierani, A;Ericson, J
在腹侧神经管中的限定位置处响应于Sonic Hedgehog（Shh）活动的梯度而产生不同类别的神经元。由神经祖细胞表达的一组同源结构域转录因子在Shh依赖的神经模式中充当中介。这些同源结构域因子分为两类：I类蛋白被Shh抑制，II类蛋白需要Shh信号来表达。I类和II类蛋白表达的概况定义了五个祖域，每个祖域产生一个不同的有丝分裂后神经元。I类和II类蛋白质之间的交叉抑制相互作用似乎改善和维持这些祖域。Nkx6.1、Nkx2.2和Irx3这三种蛋白质的组合表达确定了神经管腹侧三分之一区域中产生的三类神经元的身份。
Distinct classes of neurons are generated at defined positions in the ventral neural tube in response to a gradient of Sonic Hedgehog (Shh) activity. A set of homeodomain transcription factors expressed by neural progenitors act as intermediaries in Shh-dependent neural patterning. These homeodomain factors fall into two classes: class I proteins are repressed by Shh and class II proteins require Shh signaling for their expression. The profile of class I and class II protein expression defines five progenitor domains, each of which generates a distinct class of postmitotic neurons. Cross-repressive interactions between class I and class II proteins appear to refine and maintain these progenitor domains. The combinatorial expression of three of these proteins-Nkx6.1, Nkx2.2, and Irx3-specifies the identity of three classes of neurons generated in the ventral third of the neural tube.