SURFACE MODIFICATION OF POLYMERS FOR MEDICAL APPLICATIONS
SURFACE MODIFICATION OF POLYMERS FOR MEDICAL APPLICATIONS
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DOI：
10.1016/0142-9612(94)90025-6
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发表时间：
1994-08-01
期刊：
影响因子：
14
通讯作者：
IKADA, Y
中科院分区：
文献类型：
--
作者：
IKADA, Y
当用作生物材料时，大多数传统材料不能满足对其表面和体积性能的要求。开发临床应用的生物材料的一个有效途径是对已经具有良好生物功能和体积性能的材料进行表面改性。本文综述了聚合物的表面接枝改性技术，这种技术在聚合物化学中早已为人所知，但在生物材料中尚未得到广泛的应用。接枝表面主要可以通过单体的接枝聚合或现有聚合物分子在基材聚合物表面上的共价偶联反应来产生。需要修饰的主要表面特性包括两种生物相容性。一个是引起最少异物反应的表面特性，另一个是细胞和组织结合的能力。此外，可能需要具有例如选择性吸附能力的生理活性表面。本文简要综述了通过嫁接技术制备这些生物相容性或生物特异性表面的尝试。
Most of the conventional materials do not meet the demands required for both their surface and bulk properties when used as biomaterials. An effective approach for developing a clinically applicable biomaterial is to modify the surface of the material which already has excellent biofunctionality and bulk properties. This review article focuses on the surface modification of polymers by grafting techniques, which have long been known in polymer chemistry but are not yet widely applied to biomaterials. A grafted surface can be produced primarily either by graft polymerization of monomers or covalent coupling reaction of existing polymer molecules onto the substrate polymer surface. The major surface properties that should be modified include two kinds of biocompatibility. One is the surface property that elicits the least foreign-body reactions and the other is the cell- and tissue-bonding capability. In addition, physiologically active surfaces with, for instance, selective adsorbability may be required. Attempts to produce these biocompatible or biospecific surfaces by grafting techniques are briefly overviewed in this article.