Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity
Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity
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DOI：
10.1016/j.it.2004.09.013
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发表时间：
2004-12-01
影响因子：
16.8
通讯作者：
Heath, WR
中科院分区：
文献类型：
--
作者：
Carbone, FR;Belz, GT;Heath, WR
树突状细胞（dc）由一个异质的集合子集，许多具有独特的表型和功能特征。虽然某些亚群从外周非淋巴组织迁移，但有证据表明抗原递呈可以扩展到永久驻留在淋巴结内的dc。本意见描述了在t细胞启动和耐受性诱导的情况下，迁移和淋巴驻留dc之间抗原转移的背景下的这一发现。
Dendritic cells (DCs) consist of a heterogeneous collection of subsets, many with unique phenotypic and functional characteristics. Although certain subsets migrate from peripheral non-lymphoid tissues, there is evidence that antigen presentation can extend to DCs that permanently reside within the lymph node. This Opinion describes this finding in the context of antigen transfer between migrating and lymphoid-resident DCs in cases of T-cell priming and tolerance induction.