Murine coronavirus-induced subacute fatal peritonitis in C57BL/6 mice deficient in gamma interferon
Murine coronavirus-induced subacute fatal peritonitis in C57BL/6 mice deficient in gamma interferon
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DOI：
10.1128/jvi.72.11.9286-9290.1998
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发表时间：
1998-11-01
影响因子：
5.4
通讯作者：
Iwakura, Y
中科院分区：
文献类型：
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作者：
Kyuwa, S;Tagawa, YI;Iwakura, Y
用C57BL/6背景的伽马干扰素缺乏（IFN-GAMMA - / - ）用驼鹿肝炎病毒菌株JHM（JHMV）感染了C57BL/6背景的小鼠。与IFN-gamma - +/ - 和IFN-gamma+/+小鼠相比，JHMV持续存在于IFN-Gamma - / - 小鼠中，并诱发了感染的亚急性期的死亡。出乎意料的是，被感染的IFN-gamma - / - 小鼠在亚急性期间表现出严重的腹膜炎，伴随着粘性液在腹部和胸腔腔中的积累。未观察到肝细胞的破坏性变化。重组IFN-GAMMA的给药呈延伸性IFN-GAMMA - / - 小鼠在JHMV感染后的生存时间，这些结果表明，IFN-GAMMA在JHMV感染中在病毒清除中起关键作用。他们还表明，持续的JHMV感染在IFN-gamma - / - 小鼠中诱导了另一种形式的疾病，该疾病与猫的猫科动物感染性腹膜炎相似。
Gamma interferon-deficient (IFN-gamma-/-) mice with a C57BL/6 background were infected intraperitoneally with moose hepatitis virus strain JHM (JHMV). In contrast to IFN-gamma-+/- and IFN-gamma+/+ mice, JHMV persisted in IFN-gamma-/- mice and induced death duping the subacute phase of the infection. Unexpectedly, infected IFN-gamma-/- mice showed severe peritonitis accompanying the accumulation of a viscous fluid in the abdominal and thoracic cavities in the subacute phase. Destructive changes of hepatocytes were not observed. Administration of recombinant IFN-gamma protracted the survival time of IFN-gamma-/- mice after JHMV infection, These results demonstrate that IFN-gamma plays a critical role in viral clearance in JHMV infection. They also show that a resultant persistent JHMV infection induces another form of disease in IFN-gamma-/- mice, which bears a resemblance to feline infectious peritonitis in cats.