"Living" Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry
"Living" Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry
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DOI：
10.1002/adma.201103207
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发表时间：
2012-01-01
影响因子：
29.4
通讯作者：
Kong, Hyunjoon
中科院分区：
文献类型：
--
作者：
Jeong, Jae Hyun;Chan, Vincent;Kong, Hyunjoon
这项研究提出了一种“活的”微血管邮票，该邮票释放了多种血管生成因子，随后创建了与邮票中刻有相同模式的功能性新系列。该邮票由分泌血管生成因子的活细胞组成，一种工程的水凝胶基质，可促进血管生成因子的细胞表达，以及将血管生成因子定位在该模式中的三维几何形状。
This study presents a "living" microvascular stamp that releases multiple angiogenic factors and subsequently creates functional neovessels with the same pattern as that engraved in the stamp. The stamp consists of live cells that secrete angiogenic factors, an engineered hydrogel matrix that promotes cellular expression of angiogenic factors, and a three-dimensional geometry that localizes the angiogenic factors within the pattern.