The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy
The 2002 AJCC pT2 substages confer no prognostic information on the rate of biochemical recurrence after radical prostatectomy
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DOI：
10.1016/j.eururo.2005.12.009
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发表时间：
2006-02-01
期刊：
影响因子：
23.4
通讯作者：
Karakiewicz, PI
中科院分区：
文献类型：
--
作者：
Chun, FKH;Briganti, A;Karakiewicz, PI
简介：我们研究了AJCC pT 2亚阶段在预测根治性前列腺切除术（RP）后生化复发（BCR）的预后价值，在欧洲patients.Methods：一个队列的1726例RP患者pT 2NO前列腺癌（PCa）进行了研究。多变量考克斯回归模型分析了1997年或1992/2002年pT 2亚期（在控制总PSA、原发和继发病理Gleason评分和手术切缘状态后）与RP后PSA复发时间（PSA > 0.1并升高）之间的相关性。回归系数，然后使用多变量模型的预测精度进行测试，在诺模setting.Results：PSA复发发生在80例（4.6%）患者。平均和中位复发时间分别为28.9和24.4个月。在单变量分析中，1997年（p = 0.48）和1992/2002年pT 2亚期（p = 0.054）均不能预测复发。在多变量分析中，持续缺乏显著性（1997年p = 0.709; 1992/2002年p = 0.124）。将1997年或1992/2002年pT 2分期加入到不含pT 2分期信息的多变量列线图中，其准确性分别下降0.8%和1.1%。结论：pT 2分期与治疗前总PSA、手术切缘状态和病理Gleason评分无相关性。因此，可以假定根据Partin的病理分期足以证实器官局限性。(c)2005 Elsevier B. V.保留所有权利。
Introduction: We examined the prognostic value of AJCC pT2 substages in prediction of biochemical recurrence (BCR) after radical prostatectomy (RP), in European patients.Methods: A cohort of 1726 RP patients with pT2NO prostate cancer (PCa) was studied. Multivariate Cox regression models addressed the association between either the 1997 or 1992/2002 pT2 substages after controlling for total PSA, primary and secondary pathologic Gleason scores and surgical margin status and time to PSA recurrence (PSA > 0.1 and rising) after RP. Regression coefficients were then used to test the predictive accuracy of multivariate models in a nomogram setting.Results: PSA recurrence occurred in 80 (4.6%) patients. Mean and median times to recurrence were respectively 28.9 and 24.4 months. In univariate analyses, neither the 1997 (p = 0.48) nor the 1992/2002 pT2 substages (p = 0.054) were predictive of recurrence. In multivariate analyses the lack of significance persisted (1997 p = 0.709; 1992/2002 p = 0.124). When either the 1997 or 1992/2002 pT2 substages were added to a multivariate nomogram without pT2 substage information, its accuracy respectively decreased by 0.8% and 1.1%.Conclusion: Our data indicate that pT2 substages offer no incremental value relative to pre-treatment total PSA, surgical margin status and pathologic Gleason scores. Therefore, it might be postulated that it is sufficient to confirm organ confinement according to Partin's pathologic staging.(c) 2005 Elsevier B.V. All rights reserved.