HIF transcription factors, inflammation, and immunity.
HIF transcription factors, inflammation, and immunity.
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DOI：
10.1016/j.immuni.2014.09.008
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发表时间：
2014-10-16
期刊：
影响因子：
32.4
通讯作者：
Johnson, Randall S.
中科院分区：
文献类型：
--
作者：
Palazon, Asis;Goldrath, Ananda W.;Nizet, Victor;Johnson, Randall S.
细胞和组织中的缺氧反应由缺氧诱导因子（HIF）转录因子家族介导，所述HIF转录因子家族在驱动细胞适应低氧可用性的代谢变化中发挥不可或缺的作用。免疫细胞中HIF的表达和稳定可以由缺氧触发，但也可以由与病理应激相关的其他因素触发：例如，炎症、感染性微生物和癌症。HIF诱导宿主免疫功能的许多方面，从增强吞噬细胞杀微生物能力到驱动T细胞分化和细胞毒活性。细胞代谢正在成为免疫的关键调节因子，它构成了HIF微调免疫控制的另一层，可以决定骨髓细胞和淋巴细胞的发育，命运和功能。在这里，我们讨论了如何在免疫微环境中的氧传感形状的免疫反应，并检查如何HIF和缺氧通路控制先天性和适应性免疫。
The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF) transcription factors that play an integral role in the metabolic changes that drive cellular adaptation to low oxygen availability. HIF expression and stabilization in immune cells can be triggered by hypoxia, but also by other factors associated with pathological stress: e.g., inflammation, infectious microorganisms, and cancer. HIF induces a number of aspects of host immune function, from boosting phagocyte microbicidal capacity to driving T cell differentiation and cytotoxic activity. Cellular metabolism is emerging as a key regulator of immunity, and it constitutes another layer of fine-tuned immune control by HIF that can dictate myeloid cell and lymphocyte development, fate, and function. Here we discuss how oxygen sensing in the immune microenvironment shapes immunological response and examine how HIF and the hypoxia pathway control innate and adaptive immunity.
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