Ethanol drinking following 6-OHDA lesions of nucleus accumbens and tuberculum olfactorium of the rat.
Ethanol drinking following 6-OHDA lesions of nucleus accumbens and tuberculum olfactorium of the rat.
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大鼠伏核和嗅结节 6-OHDA 损伤后饮用乙醇。
DOI：
10.1016/0741-8329(91)90854-p
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Myers,RD
中科院分区：
文献类型：
--
作者：
Quarfordt,SD;Kalmus,GW;Myers,RD
先前的研究表明，脑室内注射神经毒素6-羟多巴胺（6-OHDA）会引起大脑多巴胺能系统的损伤，从而引起酒精饮用的显著变化。在本实验中，将6-OHDA注入嗅觉结核或核或伏隔核（这两个与药物相关强化有关的结构），损伤了sd - dawley大鼠的多巴胺能系统。在损伤之前和损伤之后，进行了乙醇偏好测试，其中在自我选择的情况下提供水和乙醇，乙醇浓度在10天的间隔内从3-30%增加。在对伏隔核或嗅结核内的多巴胺能神经元进行有限度的消融后，在第一次损伤后饮酒试验中，对乙醇的偏好显著增加，绝对摄入量在7%浓度下超过4.0 g/kg。在第二次损伤后偏好测试中，11%浓度的乙醇平均消耗量超过6.0 g/kg， 20%和30%浓度的乙醇平均消耗量超过4.0 ~ 5.0 g/kg。当这些结构的背侧或侧面的邻近区域被6-OHDA损伤时，乙醇的消耗没有发生显著变化。因此，可以设想，伏隔核和嗅结核的多巴胺能神经元的功能作用之一是调节对具有成瘾倾向的药物（如乙醇）的渴望。由于多巴胺受体正常功能受损或这种儿茶酚胺能神经递质释放紊乱，乙醇在反复暴露后变得强化。因此，一种类似上瘾的状态随之而来。最后，我们设想，在酒精消耗达到滥用程度的个体中，多巴胺能神经元功能的控制机制在功能上被去抑制。
Previous studies have shown that lesions of the dopaminergic system in the brain produced by an intracerebroventricular injection of the neurotoxin, 6-hydroxydopamine (6-OHDA), evoke significant changes in ethanol drinking. In the present experiments, dopaminergic systems of Sprague-Dawley rats were lesioned by 6-OHDA infused into either the tuberculum olfactorium or nucleus or nucleus accumbens, two of the structures implicated in drug-related re-inforcement. Prior to the lesion and immediately thereafter, tests for ethanol preference were undertaken in which water was offered in a self-selection situation together with ethanol which was increased in concentration from 3–30% over a 10-day interval. Following the circumscribed ablation of dopaminergic neurons within either the N. accumbens or tuberculum olfactorium, preference for ethanol increased significantly with absolute intakes exceeding 4.0 g/kg at the 7% concentration during the first postlesion drinking test. During the second postlesion preference test, the mean consumption of ethanol exceeded 6.0 g/kg at the 11% concentration and 4.0 to 5.0 g/kg at the 20 and 30 percent concentrations offered to the rats. When adjacent areas just dorsal or lateral to these structures were lesioned by 6-OHDA, no significant change in consumption of ethanol occurred. Thus, it is envisaged that one of the functional roles for the dopaminergic neurons of the N. accumbens and tuberculum olfactorium is to regulate the craving for a drug with addictive liability such as ethanol. As a result of an impairment of normal function of dopamine receptors or a perturbation in the release of this catecholaminergic neurotransmitter, ethanol becomes reinforcing upon repeated exposure. Thus, an addictive-like state consequently ensues. Finally, it is envisaged that the control mechanism underlying the function of the dopaminergic neurons in the medial-basal forebrain is functionally disinhibited in individuals that consume ethanol to the point of abuse.
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多重代谢理论、饮酒和产醇基因。
DOI：
--
发表时间：
1985
期刊：
Progress in clinical and biological research
影响因子：
--
作者：
Myers,RD
通讯作者：
Myers,RD
大鼠脑单胺和自由选择乙醇消耗。
影响因子：
4.2
作者：
J. Richardson;D. Novakovski
通讯作者：
D. Novakovski
影响因子：
2.3
作者：
MCBRIDE, WJ;MURPHY, JM;LI, TK
通讯作者：
LI, TK
脑室注射6-OHDA、5,6-DHT或5,7-DHT后大鼠饮酒的遗传差异
DOI：
--
发表时间：
1976
期刊：
Pharmacology, Biochemistry and Behavior
影响因子：
--
作者：
C. Melchior;R. D. Myers
通讯作者：
R. D. Myers
四氢-β-咔啉诱导大鼠饮酒的海马解剖定位。
DOI：
10.1016/0741-8329(87)90041-3
发表时间：
1987
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Huttunen,P;Myers,RD
通讯作者：
Myers,RD