Hypothalamic Gray Matter Volume Loss in Hypnic Headache
Hypothalamic Gray Matter Volume Loss in Hypnic Headache
复制标题
DOI：
10.1002/ana.22188
复制
发表时间：
2011-03-01
影响因子：
11.2
通讯作者：
Obermann, Mark
中科院分区：
文献类型：
--
作者：
Holle, Dagny;Naegel, Steffen;Obermann, Mark
目的：睡眠性头痛（HH）是一种罕见的原发性头痛疾病，其特征是严格的夜间头痛发作，大多发生在晚上的同一时间。这种疾病的病理生理学是知之甚少，但下丘脑参与被怀疑为下丘脑代表的大脑管理中心的睡眠调节和疼痛control.Methods：14例HH患者和14名年龄匹配和性别匹配的健康对照进行了调查，使用磁共振成像为基础的体素为基础的morphometry.Results：我们检测到灰质体积减少后HH患者下丘脑。额外的灰质减少被观察到与大脑疼痛处理，包括扣带皮层，鳃盖，额叶，以及在颞叶，以及在颞叶.Interpretation：我们的数据证实了假设的参与后下丘脑HH的病理生理，并强调睡眠调节和疼痛控制的重要性，这个结构。神经网络2011;69：533-539
Objective: Hypnic headache (HH) is a rare primary headache disorder characterized by strictly nocturnal headache attacks that mostly occur at the same time at night. The pathophysiology of this disease is poorly understood, but hypothalamic involvement was suspected as the hypothalamus represents the cerebral management center of sleep regulation and pain control.Methods: Fourteen patients with HH and 14 age-matched and gender-matched healthy controls were investigated using magnetic resonance imaging-based voxel-based morphometry.Results: We detected gray matter volume decrease in the posterior hypothalamus of HH patients. Additional gray matter decrease was observed in brain areas known to be associated with cerebral pain processing, including the cingulate cortex, operculum, and frontal lobe, as well as in the temporal lobe.Interpretation: Our data confirm the hypothesized involvement of the posterior hypothalamus in the pathophysiology of HH and emphasize the importance of this structure for sleep regulation and pain control. ANN NEUROL 2011;69:533-539