A Tale of Timing and Transport

A Tale of Timing and Transport
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时间和交通的故事

DOI:
10.1016/s0896-6273(03)00528-2
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发表时间:
2003
期刊:
影响因子:
16.2
通讯作者:
I. Módy
I. Módy
中科院分区:
医学1区
文献类型:
--
作者:
B. Stell;I. Módy

文献摘要

被引文献

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兴奋性和抑制性突触表现出长时程的可塑性,但尖峰时间依赖的可塑性仅见于兴奋性连接。不再是了在本期《神经元》杂志中,Woodin等人证明了突触前和突触后活动同时作用于神经元K+/Cl−协同转运蛋白KCC 2,从而改变Cl−的逆转电位,从而改变GABA能突触的有效性。
Excitatory and inhibitory synapses show long-term plasticity, but spike timing-dependent plasticity was seen only at excitatory connections. No longer. In this issue ofNeuron, Woodin et al. demonstrate that coincident pre- and postsynaptic activity acts on the neuronal K+/Cl−cotransporter KCC2 to shift the reversal potential for Cl−and thus alters the effectiveness of GABAergic synapses.