Inhibitory effect of an aromatic retinoic acid analog on urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Inhibitory effect of an aromatic retinoic acid analog on urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
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芳香族视黄酸类似物对用 N-丁基-N-(4-羟丁基)亚硝胺治疗的大鼠膀胱癌发生的抑制作用。
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
N. Ito
中科院分区：
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作者：
G. Murasaki;Y. Miyata;K. Babaya;M. Arai;S. Fukushima;N. Ito
本文研究了芳香族维甲酸类似物全反式-9-（4-甲氧基-2，3，6-三甲基苯基）-3，7-二甲基-2，4，6，8-壬四烯酸乙酯对N-丁基-N-（4-羟丁基）亚硝胺（BBN）诱发大鼠膀胱癌的抑制作用。在饮用水中加入BBN之前，在饮食中加入50 ppm芳香族维甲酸可降低膀胱上皮癌前病变乳头状或结节性增生的发生率（P < 0.05）。在BBN治疗前、治疗中或治疗后给予本品，也可显著降低乳头状瘤的发生率（BBN治疗前P < 0.001，BBN治疗中或治疗后P < 0.01），并对癌的发展有轻微的抑制作用。在BBN给药前或给药期间给予100 ppm芳香族维甲酸也可降低乳头状或结节性增生的发生率在BBN治疗前、治疗中或治疗后给予本品，可显著降低乳头状瘤的发生率（P < 0.01，P < 0.05（P < 0.001），而癌症（BBN治疗前后P < 0.01，BBN治疗期间P < 0.001）。通过评估类维生素A对组织切片中膀胱基底膜每10 cm长度的各种上皮病变的平均数量的影响，获得了类似的结果。这些结果表明，芳香族类维生素A抑制BBN诱导的大鼠膀胱癌发生的起始和促进，并且其效果是剂量依赖性的。
The inhibitory effect of an aromatic retinoic acid analog, ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate, on bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was evaluated. Administration of 50 ppm of aromatic retinoid in the diet before BBN in the drinking water reduced the incidence of papillary or nodular hyperplasia as a preneoplastic lesion of the bladder epithelium (P < 0.05). When given before, during or after BBN, it also greatly reduced the incidence of papilloma (P < 0.001 before BBN, P < 0.01 during or after BBN treatment), and slightly inhibited the development of cancer. Administration of 100 ppm of aromatic retinoid before or during BBN administration also reduced the incidences of papillary or nodular hyperplasia (P < 0.01 before BBN, P < 0.05 during BBN treatment), and its administration before, during or after BBN treatment greatly reduced the incidences of papilloma (P < 0.001), and cancer (P < 0.01 before or after BBN, P < 0.001 during BBN treatment). Similar results were obtained by assessing the effect of the retinoid on the average numbers of various epithelial lesions per 10 cm length of basement membrane of the bladder in tissue slices. These results show that the aromatic retinoid inhibits both the initiation and promotion of bladder carcinogenesis induced in rats by BBN, and that its effect is dose-dependent.