The Role of octopamine and tyramine in Drosophila larval locomotion
The Role of octopamine and tyramine in Drosophila larval locomotion
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DOI：
10.1002/cne.23152
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发表时间：
2012-11-01
影响因子：
2.5
通讯作者：
Thum, Andreas S.
中科院分区：
文献类型：
--
作者：
Selcho, Mareike;Pauls, Dennis;Thum, Andreas S.
果蝇幼虫的爬行行为是由一系列有节奏的摆动和转动头部的动作组成。最近已经显示两种生物胺章鱼胺和酪胺调节运动的各种参数，例如肌肉收缩、暂停或向前运动所花费的时间以及节律运动模式的启动和维持。通过使用具有改变的章鱼胺和酪胺水平的突变体，并通过对这两个系统的遗传干扰，我们证实了这两种胺的信号传导是幼虫运动所必需的。我们发现，一个小的一组约40章鱼胺能/酪胺能神经元腹神经索内足以触发适当的幼虫运动。使用单细胞克隆，我们单独描述这些神经元的形态。考虑到章鱼胺和酪胺在幼虫大脑中的各种潜在作用，如运动，学习和记忆，压力诱导的行为或能量状态的调节，功能往往不容易区分，我们在这里解剖第一次这个复杂的电路，特别是调制幼虫运动的一个子集。因此，这些数据将有助于理解特定的神经元调制器如何在复杂的神经元网络的不同子电路内执行特定的行为功能。神经学比较杂志520：37643785，2012。(C)2012 Wiley Periodicals，Inc.
The characteristic crawling behavior of Drosophila larvae consists of a series of rhythmic waves of peristalsis and episodes of head swinging and turning. The two biogenic amines octopamine and tyramine have recently been shown to modulate various parameters of locomotion, such as muscle contraction, the time spent in pausing or forward locomotion, and the initiation and maintenance of rhythmic motor patterns. By using mutants having altered octopamine and tyramine levels and by genetic interference with both systems we confirm that signaling of these two amines is necessary for larval locomotion. We show that a small set of about 40 octopaminergic/tyraminergic neurons within the ventral nerve cord is sufficient to trigger proper larval locomotion. Using single-cell clones, we describe the morphology of these neurons individually. Given various potential roles of octopamine and tyramine in the larval brain, such as locomotion, learning and memory, stress-induced behaviors or the regulation of the energy state, functions that are often not easy to discriminate, we dissect here for the first time a subset of this complex circuit that modulates specifically larval locomotion. Thus, these data will help to understandfor a given neuronal modulatorhow specific behavioral functions are executed within distinct subcircuits of a complex neuronal network. J. Comp. Neurol. 520:37643785, 2012. (C) 2012 Wiley Periodicals, Inc.