Myocardial contrast echocardiography in humans: I. Safety--a comparison with routine coronary arteriography.
Myocardial contrast echocardiography in humans: I. Safety--a comparison with routine coronary arteriography.
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人类心肌造影超声心动图：I. 安全性——与常规冠状动脉造影的比较。
DOI：
10.1016/s0735-1097(86)80383-7
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发表时间：
1986
影响因子：
24
通讯作者：
Kaul,S
中科院分区：
文献类型：
--
作者：
Moore,CA;Smucker,ML;Kaul,S
心肌声学造影是一种新的诊断性心血管成像技术，能够在体内确定冠状动脉血管的灌注区;最终，它可用于测量绝对区域心肌血流量。然而，在用于人类之前，必须明确其安全性。因此，在10例冠状动脉正常的受试者中，比较了冠状动脉内注射2 cc超声处理的Renografin-76与5 - 10 cc非超声处理的Renografin-76的心电图和血液动力学效应。在超声心动图检查中，2立方厘米的超声处理Renografin可提供最佳的心肌显影，而5 - 10 cc Renografin则需要进行充分的冠状动脉造影。与基线和心肌造影超声心动图相比，冠状动脉造影期间，心率降低，PR和QT间期以及QRS时限增加（p < 0.01）。同样，常规冠状动脉造影术中主动脉压和左心室压一阶导数（dP/dt）的降低显著（p < 0.01）大于心肌造影超声心动图。在心肌声学造影和冠状动脉造影中，左心室舒张末期或肺毛细血管楔压的变化相似。心肌声学造影和冠状动脉造影之间的心电图和血流动力学变化的持续时间没有显着差异。结论：冠状动脉内注射2 cc的超声Renografin-76提供了最佳的心肌显影。它在人体中是安全的，产生短暂的心电图和血流动力学改变，这些改变不如常规冠状动脉造影术中观察到的明显。
Myocardial contrast echocardiography is a new diagnostic cardiovascular imaging technique capable of defining perfusion zones of coronary vessels in vivo; ultimately, it may be used to measure absolute regional myocardial blood flow. However, before it can be used in humans, its safety must be clearly established. Accordingly, the electrocardiographic and hemodynamic effects of intracoronary injections of 2 cc of sonicated Renografin-76 were compared with 5 to 10 cc of non-sonicated Renografin-76 in 10 subjects with normal coronary arteries. Two cubic centimeters of sonicated Ren-ografin provides optimal myocardial opacification during echocardiography, while 5 to 10 cc of Renografin is required for an adequate coronary arteriogram.During coronary arteriography, heart rate decreased while PR and QT intervals and QRS duration increased as compared with baseline and myocardial contrast echocardiography (p < 0.01). Similarly, the decrease in aortic pressure and first derivative of left ventricular pressure (dP/dt) was significantly (p < 0.01) greater during routine coronary arteriography than during myocardial contrast echocardiography. Changes in left ventricular end-diastolic or pulmonary capillary wedge pressure were similar during myocardial contrast echocardiography and coronary angiography. There were no significant differences in the duration of electrocardiographic and hemodynamic changes between myocardial contrast echocardiography and coronary arteriography.It is concluded that intracoronary injection of 2 cc of sonicated Renografin-76 provides optimal myocardial opacification. It is safe in humans, producing transient electrocardiographic and hemodynamic alterations that are less pronounced than those seen during routine coronary angiography.
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DOI：
10.1016/s0021-9258(19)44032-5
发表时间：
1973
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
G. Bates;M. Schlabach
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DOI：
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发表时间：
1953
期刊：
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影响因子：
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作者：
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影响因子：
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