Aspirin for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: A Decision Analysis for the US Preventive Services Task Force
Aspirin for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: A Decision Analysis for the US Preventive Services Task Force
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DOI：
10.7326/m15-2129
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发表时间：
2016-06-21
影响因子：
39.2
通讯作者：
Whitlock, Evelyn P.
中科院分区：
文献类型：
--
作者：
Dehmer, Steven P.;Maciosek, Michael V.;Whitlock, Evelyn P.
工作背景：有证据表明，阿司匹林是有效的一级预防心血管疾病（CVD）和结直肠癌（CRC），但也增加了胃肠道（GI）和脑血管疾病的风险。目的：评估净平衡的好处和损害，从常规使用阿司匹林在临床相关的年龄，性别和CVD风险groups.Design：决策分析使用微观模拟模型。数据来源：3篇系统性证据综述。目标人群：40 - 79岁的男性和女性，10年心血管疾病风险为20%或更低，无心血管疾病病史，且无禁忌使用阿司匹林的胃肠道或脑血管疾病风险升高。时间范围：终生、20年和10年。前景：临床。干预：低剂量阿司匹林（
Background: Evidence indicates that aspirin is effective for the primary prevention of cardiovascular disease (CVD) and colorectal cancer (CRC) but also increases the risk for gastrointestinal (GI) and cerebral hemorrhages.Objective: To assess the net balance of benefits and harms from routine aspirin use across clinically relevant age, sex, and CVD risk groups.Design: Decision analysis using a microsimulation model.Data Sources: 3 systematic evidence reviews.Target Population: Men and women aged 40 to 79 years with a 10-year CVD risk of 20% or less, and no history of CVD and without elevated risk for GI or cerebral hemorrhages that would contraindicate aspirin use.Time Horizon: Lifetime, 20 years, and 10 years.Perspective: Clinical.Intervention: Low-dose aspirin (