Assessment of blood measures of n-3 polyunsaturated fatty acids with acute fish oil supplementation and washout in men and women
Assessment of blood measures of n-3 polyunsaturated fatty acids with acute fish oil supplementation and washout in men and women
复制标题
DOI：
10.1016/j.plefa.2009.05.018
复制
发表时间：
2009-07-01
影响因子：
3
通讯作者：
Stark, K. D.
中科院分区：
文献类型：
--
作者：
Metherel, A. H.;Armstrong, J. M.;Stark, K. D.
比较了基线、补充鱼油(4周)和清洗(8周)时静脉血浆、红细胞、全血和指尖刺血(0、4、8和12周)中n-3高不饱和脂肪酸(HUFA，~gt；=20个碳和~gt；=3个碳-碳双键)的变化。当n-3HUFA状态表示为n-3HUFA占总HUFA的百分比时，与EPA和DHA之和相比，各血液组分之间的相关性略强。N-3HUFA在血浆中的增加和减少更为显著，EPA对补充鱼油和停用鱼油的反应迅速(在第一周内)。血中n-3HUFA比例的性别差异也很明显，与男性(n=9)相比，女性(n=7)的二十二碳六烯酸(DHA，22：6n-3)有高于二十碳五烯酸(EPA，20：5n-3)和n-3二十二碳五烯酸(DPAn-3，22：5n-3)的趋势。需要在更大的人群中进行进一步的n-3生物标记物研究。(C)2009爱思唯尔有限公司。保留所有权利。
Changes in n-3 highly unsaturated fatty acids (HUFA, >= 20 carbons and >= 3 carbon-carbon double bonds) at baseline, during fish oil supplementation (4 weeks) and during washout (8 weeks) were compared in venous plasma, erythrocytes, whole blood and fingertip prick blood (weeks 0, 4, 8 and 12) with additional weekly fingertip prick samples. Correlations between the various blood fractions were slightly stronger when n-3 HUFA status was expressed as the percentage of n-3 HUFA in total HUFA as compared with the sum of EPA and DHA. Increases and decreases in n-3 HUFA were more dramatic in plasma, and EPA responded rapidly (within I week) with fish oil supplementation and cessation. Sex differences in the proportions of n-3 HUFA in blood were also apparent at baseline with females (n = 7) having a tendency for higher docosahexaenoic acid (DHA, 22:6n-3) relative to eicosapentaenoic acid (EPA, 20:5n-3) and n-3 docosapentaenoic acid (DPAn-3, 22:5n-3) as compared with males (n = 9). Further n-3 biomarker research in larger populations is required. (C) 2009 Elsevier Ltd. All rights reserved.