Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: Data from the European Epidemiologic Registry of Cystic Fibrosis
Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: Data from the European Epidemiologic Registry of Cystic Fibrosis
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DOI：
10.1002/ppul.1142
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发表时间：
2001-11-01
影响因子：
3.1
通讯作者：
Strandvik, B
中科院分区：
文献类型：
--
作者：
Koch, C;Rainisio, M;Strandvik, B
来自6个年龄组的7566名患者的横断面分析数据被用来比较患有和不患有囊性纤维化相关糖尿病(CFDM)的患者的肺功能、体重指数(BMI)和年龄别体重。在非糖尿病囊性纤维化(CF)患者中，10岁、10岁、15岁、15岁、15岁、20岁、20岁、25岁、30岁和30岁或以上年龄组的FEV1%预测值的平均值分别为87%、77%、69%、58%、55%和53%，而糖尿病囊性纤维化患者的预测值分别为79%、66%、55%、49%、46%和44%。除最年轻患者的BMI外，在所有年龄组中，糖尿病患者的BMI和年龄体重也低于非糖尿病患者。糖尿病患者和非糖尿病患者在肺功能和营养参数上的差异与下呼吸道有无任何特定病原体无关。这些结果证实并扩展了早期研究在较小数量的患者中的结果，他们清楚地发现慢性阻塞性肺疾病是严重肺部疾病和合并糖尿病患者存活率下降的强大决定因素。(C)2001年Wiley-Liss，Inc.
Data derived from a cross-sectional analysis of 7,566 patients stratified into six age groups were used to compare lung function, body mass index (BMI), and weight for age in patients with and without cystic fibrosis-related diabetes mellitus (CFDM).The presence of CFDM was tightly linked to poor lung function, regardless of age. The mean value of FEV1 % predicted in the age groups < 10, 10-< 15, 15-< 20, 20-< 25, 25-< 30, and 30 years or older were 87%, 77%, 69%, 58%, 55%, and 53% in the nondiabetic cystic fibrosis (CF) patients as compared to 79%, 66%, 55%, 49%, 46%, and 44% in the diabetic CF patients. BMI and weight for age were also lower in diabetic than nondiabetic CF patients in all age groups, except for BMI in the youngest patients. The difference in lung function and in nutritional parameters between diabetic and nondiabetic CF patients was not linked to presence or absence of any specific pathogen in the lower respiratory tract.These results confirm and extend those of earlier studies in smaller numbers of patients, and they clearly identify CFDM as a powerful determinant of severe lung disease and reduced survival in patients with CF and diabetis mellitus. (C) 2001 Wiley-Liss, Inc.