Sputum periostin in patients with different severe asthma phenotypes
Sputum periostin in patients with different severe asthma phenotypes
复制标题
DOI：
10.1111/all.12580
复制
发表时间：
2015-05-01
期刊：
影响因子：
12.4
通讯作者：
Quirce, S.
中科院分区：
文献类型：
--
作者：
Bobolea, I.;Barranco, P.;Quirce, S.
背景识别炎性表型与严重的未控制哮喘有关。本研究的目的是确定重症哮喘患者不同的临床、炎症、功能和分子表型，并探讨痰Periostin作为重症哮喘表型生物标志物的潜在作用。患者和方法对62例确诊为重症哮喘的患者进行诱导痰。进行皮肤点刺试验、肺功能试验、呼出一氧化氮、血常规和血清总IgE测定。结果哮喘患者中80%为晚发型哮喘，50%为固定性气流阻塞，66%为Th2高表型。在炎性表型方面，71%为嗜酸性粒细胞，25%为混合粒细胞。固定气流受限患者的Periostin水平高于可变气流受限患者(69.76pg/ml比43.84pg/ml，P
BackgroundIdentifying inflammatory phenotypes is relevant in severe uncontrolled asthma. The aim of this study was to identify the different clinical, inflammatory, functional, and molecular phenotypes in patients with severe asthma and to investigate the potential role of sputum periostin as a biomarker of severe asthma phenotypes.Patients and methodsSputum induction was performed in 62 patients diagnosed with severe asthma. Skin prick testing, lung function tests, exhaled nitric oxide, hematimetry, and total serum IgE were performed. Periostin was measured in sputum supernatants.ResultsPatients with asthma were phenotyped and 80% had late-onset asthma, 50% had fixed airflow obstruction, and 66% showed a Th2-high phenotype. With respect to inflammatory phenotypes, 71% were eosinophilic and 25% mixed granulocytic. Periostin levels were higher in patients with fixed as compared to variable airflow limitation (69.76 vs 43.84pg/ml, P