Association of breast cancer and obesity in a homogeneous population from Spain
Association of breast cancer and obesity in a homogeneous population from Spain
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DOI：
10.3275/8370
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发表时间：
2012-07-01
影响因子：
5.4
通讯作者：
Casanueva, F. F.
中科院分区：
文献类型：
--
作者：
Crujeiras, A. B.;Cueva, J.;Casanueva, F. F.
目的：首次在西班牙评估肥胖与乳腺癌预后之间的关联是否与其他非地中海饮食模式国家报告的相似。方法：从 2006 年诊断出的乳腺癌女性的医疗档案中检索体重和身高等感兴趣的变量、肿瘤特征和诊断后 3 年当前的临床状况。对 159 例信息完整的病例进行研究，并根据世界卫生组织的正常/体重不足、超重和肥胖标准进行分类。结果：乳腺癌患者中，70.4% 属于超重/肥胖，29.6% 属于正常体重。与同一地区健康女性的肥胖患病率（27.11%）相比，肥胖患病率较高（38.4%），绝经后患者以及饮酒和吸烟水平较低的女性的肥胖患病率更高。此外，与体重正常的病例（70.2%；p=0.097）相比，超重/肥胖病例（79.5%）的人类表皮生长因子受体2状态往往呈阴性，并且生存曲线往往受到体重指数的影响，尽管没有统计学意义。结论：地中海国家的乳腺癌患者中超重/肥胖现象非常普遍。我们的结果支持肥胖本身的推定影响，而不是饮食模式作为乳腺癌患者的预后因素，证明有必要进行更大规模的前瞻性研究。 (J. Endocrinol. Invest. 35: 681-685, 2012) (C)2012，Editrice Kurt's
Objective: To evaluate for the first time in Spain if the association between obesity and breast cancer prognosis is similar to that reported in other countries with non Mediterranean dietary patterns. Methods: Weight and height and other variables of interest, tumor characteristics and current clinical status 3 yr after diagnosis were retrieved from medical files of breast cancer women diagnosed during 2006. A total of 159 cases with complete information were studied and categorized according to the World Health Organization criteria in normal-/under-weight, overweight, and obese. Results: Among breast cancer patients, 70.4% were classified as overweight/obese and 29.6% as normal weight. Prevalence of obesity was high (38.4%) in comparison with information reported for healthy women of the same region (27.11%) and was higher among post-menopausal patients and in women with low level of alcohol and tobacco consumption. Moreover, overweight/obese cases (79.5%) tended to have more often human epidermal growth factor receptor 2 status negative when compared with those with normal weight (70.2%; p=0.097) and the survival curves tended to be influenced by body mass index although without statistical significance. Conclusions: Overweight/obesity in a Mediterranean country is highly prevalent among breast cancer patients. Our results support a putative influence of obesity per se and not the alimentary patterns as a prognostic factor in breast cancer patients justifying the need to perform larger prospective studies. (J. Endocrinol. Invest. 35: 681-685, 2012) (C)2012, Editrice Kurt's