Genetic variation in comC, the gene encoding competence-stimulating peptide (CSP) in Streptococcus mutans
Genetic variation in comC, the gene encoding competence-stimulating peptide (CSP) in Streptococcus mutans
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DOI：
10.1111/j.1574-6968.2006.00593.x
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发表时间：
2007-03-01
影响因子：
2.1
通讯作者：
Hosie, Arthur H. F.
中科院分区：
文献类型：
--
作者：
Allan, Elaine;Hussain, Haitham A.;Hosie, Arthur H. F.
本文报道了变形链球菌群体感应分子、能力刺激肽（CSP）编码基因comC的遗传变异。在36个地理上不同的菌株中鉴定出7个comC等位基因编码3个不同的成熟csp，尽管与肺炎链球菌相比，预测的氨基酸序列变异量较低。与其他研究一致，在这些菌株中发现了DNA摄取自然能力的显著差异。然而，CSP基因型与转化这些菌株的能力之间没有相关性。编码每种CSP变体的代表性菌株对每种类型的合成CSP都有反应。因此，与肺炎链球菌相比，变形链球菌的comC等位基因在功能上是等同的，没有表型特异性的证据。
The genetic variability in comC, the gene encoding the quorum-sensing molecule, competence-stimulating peptide (CSP) in Streptococcus mutans is reported. Seven comC alleles encoding three distinct mature CSPs were identified among 36 geographically diverse strains, although, compared with Streptococcus pneumoniae, the amount of predicted amino acid sequence variation is low. In agreement with other studies, significant variation was found in the natural competence for DNA uptake in these strains. However, there was no correlation between the CSP genotype and the ability to transform these strains. Representative strains encoding each of the CSP variants became competent in response to synthetic CSPs of each type. Therefore, in contrast to S. pneumoniae, comC alleles in S. mutans are functionally equivalent and there is no evidence of pherotype specificity.