Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons
Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons
复制标题
DOI：
10.1074/jbc.272.34.20975
复制
发表时间：
1997-08-22
影响因子：
4.8
通讯作者：
Lazdunski, M
中科院分区：
文献类型：
--
作者：
Waldmann, R;Bassilana, F;Lazdunski, M
我们已经克隆并表达了一个新的质子门控Na+通道亚基，是特定的感觉神经元。在COS细胞中，它形成了一个Na+通道，该通道对细胞外pH值的下降做出响应，具有快速失活和持续的Na+电流。这种双相动力学与背根神经节感觉神经元中描述的H+门控电流非常相似（1）。这种新的H+门控Na+通道亚基在感觉神经元中的丰度和通道的动力学表明，它是负责感觉神经元中持续H+激活阳离子电流的通道复合物的一部分，这被认为对伴随组织酸中毒的疼痛的长期感知很重要（1，2）。
We have cloned and expressed a novel proton-gated Na+ channel subunit that is specific for sensory neurons. In COS cells, it forms a Na+ channel that responds to a drop of the extracellular pH with both a rapidly inactivating and a sustained Na+ current, This biphasic kinetic closely resembles that of the H+-gated current described in sensory neurons of dorsal root ganglia (1). Both the abundance of this novel H+-gated Na+ channel subunit in sensory neurons and the kinetics of the channel suggest that it is part of the channel complex responsible for the sustained H+-activated cation current in sensory neurons that is thought to be important for the prolonged perception of pain that accompanies tissue acidosis (1, 2).