Novel synthesis of gem-dichloroaziridines from imines via the KF/Al2O3-promoted generation of dichlorocarbene from chloroform.
Novel synthesis of gem-dichloroaziridines from imines via the KF/Al2O3-promoted generation of dichlorocarbene from chloroform.
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DOI：
10.1021/jo050321z
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发表时间：
2005-05
期刊：
影响因子：
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通讯作者：
Masatoshi Mihara;Y. Ishino;S. Minakata;M. Komatsu
中科院分区：
文献类型：
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作者：
Masatoshi Mihara;Y. Ishino;S. Minakata;M. Komatsu
KF/Al(2O)O(3)是亚胺与氯仿在乙腈中反应生成GEM-二氯氮杂环丙烷2的有效碱。KF/Al(2)O(3)促进的二氯氮杂环化反应可以通过简单的操作进行，可以容忍亚胺中存在的各种官能团，并且可以在较少的卡宾源的情况下顺利进行。
KF/Al(2)O(3) was found to be an efficient base for the reaction of imines with chloroform in acetonitrile to give gem-dichloroaziridines 2 in moderate to high yields. The KF/Al(2)O(3)-promoted dichloroaziridination can be carried out with simple workup, tolerates a variety of functional groups present in the imines, and proceeds smoothly with a smaller amount of carbene source.