SELENIUM IN DIET, BLOOD, AND TOENAILS IN RELATION TO HUMAN HEALTH IN A SELENIFEROUS AREA
SELENIUM IN DIET, BLOOD, AND TOENAILS IN RELATION TO HUMAN HEALTH IN A SELENIFEROUS AREA
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DOI：
10.1093/ajcn/53.5.1288
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发表时间：
1991-05-01
影响因子：
7.1
通讯作者：
WILLETT, WC
中科院分区：
文献类型：
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作者：
LONGNECKER, MP;TAYLOR, PR;WILLETT, WC
为了确定高膳食硒摄入量是否与不良反应有关，研究了居住在南达科他州西部和怀俄明州东部的成年人饮食、血液和脚趾甲中的硒与人类健康的关系。在两年的时间里，142名受试者从随机选择的家庭和怀疑有异常高硒摄入量的牧场招募而来。受试者填写健康问卷，接受体检，提供供临床评估的血样，并提供血液、尿液、脚趾甲和复盘食物以进行硒分析。在142名自由生活的受试者中，约有一半人的硒摄入量为2.54 mU·mol/d(200 mU·g/d)(范围为0.86-9.20 mU·mol/d，或68-724 mU·g/d)。实验室测试或与血液、脚趾甲或饮食中的硒相关的症状的频率没有出现具有硒毒性特征的物理发现，也没有临床上的显著变化。我们发现，在摄入量高达9.20-mU-mol/d(724-mU-g/d)的受试者中，没有发现硒的毒性证据。
To determine whether high dietary selenium intake was associated with adverse effects, selenium in diet, blood, and toenails was studied in relation to human health in adults residing in western South Dakota and eastern Wyoming. Over a 2-y period 142 subjects were recruited from households selected at random and from ranches where unusually high selenium intakes were suspected. Subjects completed health questionnaires, underwent physical examinations, provided blood samples for clinical assessment, and provided blood, urine, toenails, and duplicate-plate food collections for selenium analysis. About half of the 142 free-living subjects had selenium intakes > 2.54 mu-mol/d (200-mu-g/d) (range 0.86-9.20-mu-mol/d, or 68-724-mu-g/d). Physical findings characteristic of selenium toxicity were not present nor were clinically significant changes in laboratory tests or frequency of symptoms related to selenium in the blood, toenails, or diet. We found no evidence of toxicity from selenium in subjects whose intake was as high as 9.20-mu-mol/d (724-mu-g/d).