Gene expression analysis reveals the dysregulation of immune and metabolic pathways in Alzheimer's disease.
Gene expression analysis reveals the dysregulation of immune and metabolic pathways in Alzheimer's disease.
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基因表达分析揭示阿尔茨海默病中免疫和代谢途径的失调
DOI：
10.18632/oncotarget.12505
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发表时间：
2016-11-08
期刊：
影响因子：
--
通讯作者：
Yao L
中科院分区：
文献类型：
--
作者：
Chen J;Xie C;Zhao Y;Li Z;Xu P;Yao L
近年来，一些全基因组关联研究的通路分析报告了代谢和免疫通路在阿尔茨海默病(AD)中的参与。到目前为止，这些通路在阿尔茨海默病中的确切机制仍不清楚。在这里，我们对来自人类颞叶皮质组织的全基因组AD病例对照表达数据集(n=41，25例AD病例和16例对照)进行了通径分析。利用差异表达的AD基因，我们确定了与代谢和免疫过程相关的重要KEGG通路。利用上调和下调的AD基因列表，我们进一步发现上调的AD基因在免疫和代谢途径中显著丰富。我们进一步比较了来自表达数据集中的免疫和代谢KEGG通路与以前的GWAS数据集中的那些，发现这些通路中的大多数在GWAS和表达数据集中都是共享的。
In recent years, several pathway analyses of genome-wide association studies reported the involvement of metabolic and immune pathways in Alzheimer's disease (AD). Until now, the exact mechanisms of these pathways in AD are still unclear. Here, we conducted a pathway analysis of a whole genome AD case-control expression dataset (n=41, 25 AD cases and 16 controls) from the human temporal cortex tissue. Using the differently expressed AD genes, we identified significant KEGG pathways related to metabolism and immune processes. Using the up- and down- regulated AD gene list, we further found up-regulated AD gene were significantly enriched in immune and metabolic pathways. We further compare the immune and metabolic KEGG pathways from the expression dataset with those from previous GWAS datasets, and found that most of these pathways are shared in both GWAS and expression datasets.