Social isolation stress impairs passive avoidance learning in senescence-accelerated mouse (SAM)
Social isolation stress impairs passive avoidance learning in senescence-accelerated mouse (SAM)
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DOI：
10.1016/j.brainres.2005.10.042
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发表时间：
2006-01-05
期刊：
影响因子：
2.9
通讯作者：
Kubo, C
中科院分区：
文献类型：
--
作者：
Chida, Y;Sudo, N;Kubo, C
尽管越来越多的证据表明，社会心理压力对痴呆症患者的学习/记忆功能有不利影响，但这种影响背后的确切神经生物学机制仍不清楚。衰老加速小鼠倾向10 （SAMP10）菌株是一种神经退行性痴呆模型，从5周龄开始长期暴露于社会隔离压力下。12周龄时，分别采用单次被动回避法和y迷宫法评价条件反射记忆和空间记忆。慢性社会隔离压力显著降低条件反射记忆，但不影响空间记忆。尽管进一步的行为任务使用升高的正迷宫和疼痛阈值测试显示应激性镇痛，协方差分析排除了这种镇痛可能有助于应激性条件反射记忆损伤的可能性。此外，内分泌学和免疫组织化学分析显示，隔离应激升高了血清皮质酮水平，抑制了被动回避学习过程中调节记忆所需的中央杏仁核（CeA） c-Fos表达的增加。综上所述，慢性社会隔离应激加剧了SAM小鼠的条件反射记忆，可能是通过糖皮质激素介导的CeA神经激活的减少。(c) 2005 Elsevier B.V.版权所有
Despite cumulative evidence showing the detrimental effect of psychosocial stress on the learning/memory functions in dementia diseases, the precise neurobiological mechanisms behind such an effect remain unclear. Mice of the senescence-accelerated mice prone 10 (SAMP10) strain, a neurodegenerative dementia model, were chronically exposed to social isolation stress from the age of 5 weeks. At the age of 12 weeks, conditioning memory and spatial memory were evaluated by one-trial passive avoidance and Y-maze tests, respectively. Chronic social isolation stress significantly reduced conditioning memory but did not affect spatial memory. Although further behavioral tasks using an elevated plus maze and a pain threshold test exhibited stress-induced analgesia, an analysis of covariance excluded the possibility that such analgesia might contribute to the stress-induced impairment of conditioning memory. in addition, endocrinological and immunohistochemical analysis revealed that isolation stress elevated the serum corticosterone levels and inhibited the increase in c-Fos expression in the central amygdaloidal nucleus (CeA) that is required for conditioning memory during passive avoidance learning. in conclusion, chronic social isolation stress exacerbated conditioning memory in SAM mice, probably through a glucocorticoid-mediated decrease in neural activation in the CeA. (c) 2005 Elsevier B.V. All rights reserved.