Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections
Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections
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DOI：
10.1016/j.intimp.2012.11.020
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发表时间：
2013-02-01
影响因子：
5.6
通讯作者：
Hrubisko, Martin
中科院分区：
文献类型：
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作者：
Jesenak, Milos;Majtan, Juraj;Hrubisko, Martin
目的：反复呼吸道感染(RRTI)是临床上一个非常重要的问题，因为它对儿童的发病率有很大的影响。几种天然营养补充剂已被用于预防呼吸道感染，但只有少数几种制剂的临床疗效得到了科学证据的支持。材料和方法：在一项双盲、安慰剂对照、随机、多中心研究中，我们观察了175名儿童(年龄5.65+/-239岁)在研究开始前12个月内发生5次以上呼吸道感染。儿童被随机分成一组，服用Imunoglukan P4H(R)糖浆(含有平菇中的侧耳-β-葡聚糖和维生素C)，或安慰剂组(仅维生素C)。在为期12个月的3次访问中，完成了问卷调查，并对血液样本进行了免疫参数检查。结果：活动组36%的儿童在整个治疗过程中没有发生任何呼吸道感染，而安慰剂组有21%的儿童在整个治疗过程中没有发生任何呼吸道感染(P
Objectives: Recurrent respiratory tract infections (RRTIs) represent a very important problem in daily clinical practice because of their significant contribution to morbidity in children. Several natural nutritional supplements have been used in the prevention of RRTIs, but the clinical efficacy of only a few preparations is supported by scientific evidence.Materials and methods: In a double-blind, placebo-controlled, randomised, multicentre study, we have observed a group of 175 children (aged 5.65 +/- 239 years) with more than 5 respiratory infections that occurred during the 12 months prior to the beginning of the study. Children were randomised into an active group, treated with Imunoglukan P4H (R) syrup (with pleuran-beta-glucan from Pleurotus ostreatus and vitamin C), or a placebo group (vitamin C only). During the 3 visits, within a 12-month period, questionnaires were completed, and blood samples were examined for immune parameters.Results: In the active group, 36% of the children did not suffer from any respiratory infections throughout the treatment, compared to 21% in the placebo group (p