Structure of a left-handed DNA G-quadruplex
Structure of a left-handed DNA G-quadruplex
复制标题
DOI：
10.1073/pnas.1418718112
复制
发表时间：
2015-03-03
影响因子：
11.1
通讯作者：
Anh Tuan Phan
中科院分区：
文献类型：
--
作者：
Chung, Wan Jun;Heddi, Brahim;Anh Tuan Phan
除了众所周知的双螺旋结构外，DNA还可以采用另一种四链结构，即g -四链结构。这种结构在细胞过程中的意义，以及它的治疗和诊断应用，已经被报道过。g -四重结构是高度多晶的，但到目前为止，只观察到右手螺旋结构。本文介绍了左旋DNA g -四重体的核磁共振溶液和x射线晶体结构。该结构显示出前所未有的特征，可以作为独特的识别元素加以利用。
Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, aswell as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.