Regional impairment of cerebral oxidative metabolism in Parkinson's disease.
Regional impairment of cerebral oxidative metabolism in Parkinson's disease.
复制标题
帕金森病脑氧化代谢的区域性损伤。
DOI：
10.1136/jnnp.42.1.59
复制
发表时间：
1979
期刊：
影响因子：
--
通讯作者：
S. Moss
中科院分区：
文献类型：
--
作者：
G. Lenzi;T. Jones;J. Reid;S. Moss
Twenty-two patients affected by idiopathic Parkinsonism were studied using the oxygen-15 inhalation technique. The production of labelled metabolic water was found to be decreased in the parietal cerebral cortex, indicating an impairment in oxidative metabolism. This metabolic defect was localised mainly to the parietal cortex of the affected hemispheres; in non-affected hemispheres of patients presenting with unilateral Parkinsonism, the uptake was normal. In contrast, regional blood flow was not significantly altered. It is possible that this metabolic impairment is caused by chronic deafferentation.
