A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain
复制标题
DOI：
10.1016/j.bmcl.2013.03.121
复制
发表时间：
2013-06-15
影响因子：
2.7
通讯作者：
Duffy, Joseph L.
中科院分区：
文献类型：
--
作者：
Hoyt, Scott B.;London, Clare;Duffy, Joseph L.
A series of benzazepinones were synthesized and evaluated for block of Na(v)1.7 sodium channels. Compound 30 from this series displayed potent channel block, good selectivity versus other targets, and dose-dependent oral efficacy in a rat model of neuropathic pain. (C) 2013 Elsevier Ltd. All rights reserved.
