HUGIn: Hi-C Unifying Genomic Interrogator
HUGIn: Hi-C Unifying Genomic Interrogator
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DOI：
10.1093/bioinformatics/btx359
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发表时间：
2017-12-01
期刊：
影响因子：
5.8
通讯作者：
Li, Yun
中科院分区：
文献类型：
--
作者：
Martin, Joshua S.;Xu, Zheng;Li, Yun
动机：高通量染色质构象捕获（3C）技术，如Hi-C和ChIA-PET，有可能阐明非编码变体的功能作用。然而，大多数已发表的全基因组无偏见的染色质组织的研究都使用培养的细胞系，限制了他们的generalizability.Results：我们开发了一个网络浏览器，HUGIn，可视化Hi-C数据产生的21人的主要组织和细胞系。HUGIn能够在任何基因组位点（包括GWAS SNP、eQTL和顺式调控元件）评估组织和/或细胞系的组成性和特异性染色质接触，促进对GWAS和eQTL结果以及功能基因组学数据的理解。
Motivation: High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.Results: We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell lines. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTL results and functional genomics data.