A tumor‐associated antigen expressed in melanoma cells with lower malignant potential
A tumor‐associated antigen expressed in melanoma cells with lower malignant potential
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在恶性潜能较低的黑色素瘤细胞中表达的肿瘤相关抗原
DOI：
10.1002/ijc.2910350615
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发表时间：
1985
影响因子：
6.4
通讯作者：
C. Sorg
中科院分区：
文献类型：
--
作者：
L. Suter;J. Brüggen;E. Bröcker;C. Sorg
在痣和黑色素瘤中发现了可被单抗检测到的K-1-2抗原。K-1-2与低侵袭和转移潜能的黑色素瘤细胞有关，通过对细胞系、活检和尸检的免疫过氧化物酶研究表明：K-1-2存在于黑色素瘤细胞系SK-MEL 25中，但不存在于细胞系A-375中。A-375比SK-Mel 25具有更高的恶性潜能，因为与SK-Mel 25相比，A-375会产生纤溶酶原激活剂，并在裸鼠体内生长。K-1-2在平面(1.5 mm)肿瘤中呈强阳性表达(≥阳性细胞占50%)，在中、厚原发肿瘤中表达较少。在厚厚的原发黑色素瘤中，K-1-2阳性细胞局限于肿瘤的交界区或边缘平坦区。K-1-2很少出现在转移瘤中。在18个月的观察期内，K-1-2抗原的强表达在发生早期转移的原发黑色素瘤中较少发现，在没有转移的肿瘤中。在5例播散性转移性疾病患者中，同时或在不同时间观察到K-1-2强表达和K-1-2阴性或仅含有少量K-1-2阳性细胞的转移。这些发现表明，在动物系统中观察到的从高度恶性到低恶性的变化也可能发生在人类黑色素瘤中。
The antigen K‐1‐2, detectable by a MAb is found in nevi and melanomas. It is associated with melanoma cells of low invasive and metastatic potential as shown by immunoperoxidase studies with cell lines, biopsies and autopsies: K‐1‐2 occurs in melanoma cell line SK‐Mel 25, but not in cell line A‐375. A‐375 has a higher malignant potential than SK‐Mel 25 because, in contrast to SK‐Mel 25, it produces plasminogen activator and grows in nude mice. K‐1‐2 was frequently strongly expressed (≥ 50% cells positive) in flat (< 1.5 mm) and less frequently in medium and thick primary tumors. In thick primary melanomas K‐1‐2 positive cells were confined to the junctional zone or to marginal, flat areas of the tumor. Only rarely does K‐1‐2 occur in metastases. Strong expression of the K‐1‐2 antigen was found less often in primary melanomas, which develop early metastases, than in tumors that had not metastasized during an observation period of 18 months. In 5 patients with disseminated metastatic disease, metastases strongly expressing K‐1‐2 and those negative for this marker or containing only a minor percentage of K‐1‐2 positive cells were observed simultaneously or at different times. These findings suggest that a change from high malignancy to low malignancy—as observed in animal systems—may also occur in human melanoma.
手术切除的原发性和自体转移性人类黑色素瘤病变的抗原异质性。
DOI：
--
发表时间：
1983
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Natali,PG;Cavaliere,R;Bigotti,A;Nicotra,MR;Russo,C;Ng,AK;Giacomini,P;Ferrone,S
通讯作者：
Ferrone,S
B16 小鼠黑色素瘤中与自发转移相关的表型多样性的产生。
影响因子：
11.2
作者：
Stackpole,CW
通讯作者：
Stackpole,CW