The hypolipidemic effect of locust bean gum food products in familial hypercholesterolemic adults and children.
The hypolipidemic effect of locust bean gum food products in familial hypercholesterolemic adults and children.
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DOI：
10.1093/ajcn/38.2.285
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发表时间：
1983-08
期刊：
影响因子：
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通讯作者：
J. Zavoral;P. Hannan;D. Fields;M. Hanson;I. Frantz;K. Kuba;P. Elmer;D. Jacobs
中科院分区：
文献类型：
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作者：
J. Zavoral;P. Hannan;D. Fields;M. Hanson;I. Frantz;K. Kuba;P. Elmer;D. Jacobs
17名成人和11名儿童，一组18名家族性高胆固醇血症（FHC）和10名正常受试者，被喂食含和不含刺槐豆胶（LBG）的产品（8至30 g/天），以评估LBG的降血脂作用。使用交叉设计，由两组（A和B）任意分配的患者食用含和不含LBG的相同食品。血浆胆固醇，低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇，极低密度脂蛋白胆固醇和甘油三酯进行了测量，在2周的时间间隔，并与对照喂养期。在A组中，FHC C降低10%和LDL-C降低11%，正常人C降低6%和LDL-C降低10%（p <0.001）。在B组中，FHC C降低17%，LDL-C降低19%，正常受试者胆固醇降低11%，LDL-C降低6%（p <0.001）。两组FHC儿童的胆固醇和LDL-C均降低。两组的高密度脂蛋白/低密度脂蛋白比值均升高。在儿童和成人中使用LBG食品是治疗FHC的独特方法。LBG食物接受性良好，没有明显的副作用。食品中的LBG似乎是一种有效、安全的控制高脂血症的方法。
Seventeen adults and 11 children, a group of 18 familial hypercholesterolemic (FHC) and 10 normal subjects, were fed products with and without locust bean gum (LBG) (8 to 30 g/day) to assess the hypolipidemic effect of LBG. Identical food products with and without LBG were consumed by two groups (A and B) of arbitrarily assigned patients using a cross-over design. Plasma cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol and triglycerides were measured at 2-wk intervals and compared to control feeding periods. In group A, FHC C decreased 10% and LDL-C 11%, normal subjects decreased C 6% and LDL-C 10% (p less than 0.001). In group B, FHC C decreased 17% and LDL-C 19%, normal subjects decreased cholesterol 11%, and LDL-C 6% (p less than 0.001). Cholesterol and LDL-C were lowered in FHC children in both groups. High-density lipoprotein/LDL ratios increased in both groups. The use of food products with LBG in children and adults is a unique approach to treating FHC. LBG food acceptance was good, and there were no significant side effects. LBG in food products appears to be an effective, safe approach to controlling hyperlipidemia.