Modeling transcranial electrical stimulation in the aging brain
Modeling transcranial electrical stimulation in the aging brain
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DOI：
10.1016/j.brs.2020.02.007
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发表时间：
2020-05-01
影响因子：
7.7
通讯作者：
Woods, Adam J.
中科院分区：
文献类型：
--
作者：
Indahlastari, Aprinda;Albizu, Alejandro;Woods, Adam J.
背景：经颅电刺激（tES）接受者的不同治疗结果可能取决于到达大脑的电流量。与正常衰老相关的脑萎缩可能影响tES电流输送到大脑。已经采用计算模型来计算脑内的预测tES电流。本研究是迄今为止使用计算机模型研究健康老年人tES场分布的规模最大的研究。方法：对587名健康老年人（平均年龄73.9岁，51 - 95岁）进行个体化头部模型构建，以创建场分布图。使用具有修改代码的ROAST对具有2 mA输入电流的两个电极导联（F3-F4、M1-SO）进行建模。健康老年人的定制模板UFAB-587是从同一数据集创建的，并用于将个体大脑扭曲到同一空间。翘曲模型进行了分析，以确定计算领域的措施，脑萎缩和age.Main结果之间的关系：计算领域的措施与脑萎缩呈负相关（R-2 = 0.0829，p = 1.14e-12）。大脑亚区（包括DLPFC部分和中央前回）的场模式与年龄呈负相关。中介分析显示，年龄和电流密度之间的负相关性是部分介导的脑-CSF ratio. Conclusions：计算字段的措施表明，减少量的tES电流达到大脑萎缩的增加。因此，通过基于萎缩程度修改老年人中的tES刺激参数来调整电流剂量对于实现期望的刺激益处可能是必要的。这项研究的结果可能会为未来tES在健康老年人中的应用提供信息。(C)2020作者爱思唯尔公司出版
Background: Varying treatment outcomes in transcranial electrical stimulation (tES) recipients may depend on the amount of current reaching the brain. Brain atrophy associated with normal aging may affect tES current delivery to the brain. Computational models have been employed to compute predicted tES current inside the brain. This study is the largest study that uses computational models to investigate tES field distribution in healthy older adults.Methods: Individualized head models from 587 healthy older adults (mean = 73.9years, 51-95 years) were constructed to create field maps. Two electrode montages (F3-F4, M1 -SO) with 2 mA input current were modeled using ROAST with modified codes. A customized template of healthy older adults, the UFAB-587, was created from the same dataset and used to warp individual brains into the same space. Warped models were analyzed to determine the relationship between computed field measures, brain atrophy and age.Main results: Computed field measures were inversely correlated with brain atrophy (R-2 = 0.0829, p = 1.14e-12). Field pattern showed negative correlation with age in brain sub-regions including part of DLPFC and precentral gyrus. Mediation analysis revealed that the negative correlation between age and current density is partially mediated by brain-to-CSF ratio.Conclusions: Computed field measures showed decreasing amount of tES current reaching the brain with increasing atrophy. Therefore, adjusting current dose by modifying tES stimulation parameters in older adults based on degree of atrophy may be necessary to achieve desired stimulation benefits. Results from this study may inform future tES application in healthy older adults. (C) 2020 The Authors. Published by Elsevier Inc.