Cerebral haemodynamic changes accompanying cognitive impairment in primary lateral sclerosis
Cerebral haemodynamic changes accompanying cognitive impairment in primary lateral sclerosis
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DOI：
10.1080/17482960802411740
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发表时间：
2008-01-01
影响因子：
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通讯作者：
Lee, Ting-Yim
中科院分区：
文献类型：
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作者：
Murphy, Matthew J.;Grace, Gloria M.;Lee, Ting-Yim
我们的目的是阐明偏头痛患者认知功能减退与脑血流动力学的关系。我们检查了18例偏头痛患者，并将神经心理和脑血流灌注结果与7名年龄和教育程度相匹配的非偏头痛对照进行了对比。根据神经心理测试的异常次数将患者分为两组：1)认知功能正常的PLS患者(1)，0分或1分异常者(n=14)；2)认知受损的患者(PLSci，2分或2分以上异常者，4例)。在认知功能水平上有相当大的异质性，有4名患者符合认知障碍的标准。这一发现与额颞叶功能障碍高度一致。CT脑血流动力学检查显示，PLSci组脑血容量(CBV)和平均通过时间(MTT)增加，脑血流量(CBF)减少。更具体地说，MTT值显著增加(PB
Our objective was to elucidate the relationship between cognitive decline and cerebral haemodynamics in patients with PLS. We examined 18 patients with PLS and contrasted both neuropsychological and cerebral perfusion findings with seven age-and education-matched non-PLS controls. PLS patients were stratified into two groups based on the number of abnormal neuropsychological test scores: 1) cognitively intact PLS patients (PLS; those having zero or one abnormal scores (n = 14)), and 2) cognitively-impaired PLS patients (PLSci; those having two or more abnormal test scores (n = 4)). There was considerable heterogeneity in level of cognitive functioning with four patients meeting the criteria for cognitive impairment. The findings were highly consistent with a frontotemporal lobar dysfunction. Using CT perfusion to assess cerebral haemodynamics, the PLSci group had increased cerebral blood volume (CBV) and mean transit time (MTT) with reduced cerebral blood flow (CBF). More specifically, MTT was significantly increased (pB