Non-treatment-seeking heavy drinkers: Effects of chronic cigarette smoking on brain structure
Non-treatment-seeking heavy drinkers: Effects of chronic cigarette smoking on brain structure
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DOI：
10.1016/j.drugalcdep.2006.08.003
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发表时间：
2007-02-23
影响因子：
4.2
通讯作者：
Meyerhoff, Dieter J.
中科院分区：
文献类型：
--
作者：
Durazzo, Timothy C.;Cardenas, Valerie A.;Meyerhoff, Dieter J.
我们之前报道了[Cardenas，V.A.，Studholme，C.，Meyerhoff，D.J.，Song，E.，Weiner，M.W.，2005。长期活跃的大量饮酒和问题饮酒的家族史调节了局部脑组织的体积。精神病学研究138,115-130]没有寻求治疗，经常酗酒的人(HD)与少量饮酒的对照组相比，表现出较小的区域新皮质灰质体积；然而，长期吸烟对区域大脑体积的潜在影响并未得到解决。这项回顾分析的目的是确定长期吸烟是否会影响我们早期报告(即Cardenas等人，2005年)中未寻求治疗的大量饮酒样本的大脑结构。对年龄匹配的吸烟HD(n=17)、不吸烟HD(n=16)和不吸烟轻度饮酒者(nsLD；n=20)进行区域体积比较。从高分辨率磁共振成像获得新皮质灰质(GM)、白质(WM)、皮质下结构和脑脊液(CSF)的定量体积测量结果。吸烟的HD在额叶、顶叶、颞叶GM和总的新皮质GM的体积比nsLD小。吸烟的HD也显示出比不吸烟的HD更小的时间和总的GM体积。不吸烟的HD和nsLD在GM音量上没有显著差异。此外，三组在脑叶WM、皮质下结构或区域脑脊液体积方面没有差异。这些回顾分析表明，在不寻求治疗的吸烟HD中，新皮质GM体积减少，但在不吸烟的HID中没有，这与我们在最近戒毒治疗寻求酒精依赖的样本中的研究一致。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
We previously reported [Cardenas, V.A., Studholme, C., Meyerhoff, D.J., Song, E., Weiner, M.W., 2005. Chronic active heavy drinking and family history of problem drinking modulate regional brain tissue volumes. Psychiatry Res. 138, 115-130] that non-treatment-seeking, active heavy drinkers (HD) demonstrated smaller regional neocortical gray matter volumes compared to light drinking controls; however, the potential effects of chronic cigarette smoking on regional brain volumes were not addressed. The goal of this retrospective analysis was to determine if chronic smoking affected brain structure in the non-treatment-seeking heavy drinking sample from our earlier report (i.e., Cardenas et al., 2005). Regional volumetric comparisons were made among age-matched smoking HD (n = 17), non-smoking HD (n = 16), and non-smoking light drinkers (nsLD; n = 20) from our original sample. Quantitative volumetric measures of neocortical gray matter (GM), white matter (WM), subcortical structures, and cerebral spinal fluid (CSF) were derived from high-resolution magnetic resonance imaging. Smoking HD demonstrated smaller volumes than nsLD in the frontal, parietal, temporal GM, and for total neocortical GM. Smoking HD also demonstrated smaller temporal and total GM volumes than non-smoking HD. Non-smoking HD and nsLD did not differ significantly on GM volumes. Further, the three groups did not differ on lobar WM, subcortical structures or regional CSF volumes. These retrospective analyses indicate neocortical GM volume reductions in non-treatment-seeking smoking HD, but not in non-smoking HID, which are consistent with our studies in recently detoxified treatment-seeking alcohol-dependent samples. (c) 2006 Elsevier Ireland Ltd. All rights reserved.