Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function.
Mucosal-associated invariant T cells restrict reactive oxidative damage and preserve meningeal barrier integrity and cognitive function.
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DOI：
10.1038/s41590-022-01349-1
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发表时间：
2022-12
影响因子：
30.5
通讯作者：
Yang, Qi
中科院分区：
文献类型：
--
作者：
Zhang, Yuanyue;Bailey, Jacob T.;Xu, En;Singh, Kunal;Lavaert, Marieke;Link, Verena M.;D'Souza, Shanti;Hafiz, Alex;Cao, Jian;Cao, Gaoyuan;Sant'Angelo, Derek B.;Sun, Wei;Belkaid, Yasmine;Bhandoola, Avinash;McGavern, Dorian B.;Yang, Qi
Increasing evidence indicates close interaction between immune cells and the brain, revising the traditional view of the immune privilege of the brain. However, the specific mechanisms by which immune cells promote normal neural function are not entirely understood. Mucosal associated invariant T cells (MAIT) are a unique type of innate-like T cells whose molecular and functional properties remain to be better characterized. Here we report that MAIT cells are present in the meninges and express high levels of antioxidant molecules. MAIT cell deficiency in mice results in the accumulation of reactive oxidative species (ROS) in the meninges, leading to reduced expression of junctional protein and meningeal barrier leakage. The presence of MAIT cells restricts neuroinflammation in the brain and preserves learning and memory. Together, our work reveals a new functional role for MAIT cells in the meninges and suggests that meningeal immune cells can help maintain normal neural function by preserving meningeal barrier homeostasis and integrity.
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影响因子：
64.8
作者：
Filiano AJ;Xu Y;Tustison NJ;Marsh RL;Baker W;Smirnov I;Overall CC;Gadani SP;Turner SD;Weng Z;Peerzade SN;Chen H;Lee KS;Scott MM;Beenhakker MP;Litvak V;Kipnis J
通讯作者：
Kipnis J
影响因子：
2.4
作者：
Kashiba M;Terashima M;Sagawa T;Yoshimura S;Yamamoto Y
通讯作者：
Yamamoto Y
脑膜免疫调节学习和记忆：IL-4 的关键作用。
影响因子：
15.3
作者：
Derecki, Noel C.;Cardani, Amber N.;Yang, Chun Hui;Quinnies, Kayla M.;Crihfield, Anastasia;Lynch, Kevin R.;Kipnis, Jonathan
通讯作者：
Kipnis, Jonathan
影响因子：
30.5
作者：
Alves de Lima K;Rustenhoven J;Da Mesquita S;Wall M;Salvador AF;Smirnov I;Martelossi Cebinelli G;Mamuladze T;Baker W;Papadopoulos Z;Lopes MB;Cao WS;Xie XS;Herz J;Kipnis J
通讯作者：
Kipnis J
DOI：
10.1084/jem.20202717
发表时间：
2021-09-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chen Y;Colonna M
通讯作者：
Colonna M