Low systemic blood flow and pathophysiology of the preterm transitional circulation
Low systemic blood flow and pathophysiology of the preterm transitional circulation
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DOI：
10.1016/j.earlhumdev.2005.03.006
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发表时间：
2005-05-01
影响因子：
2.5
通讯作者：
Kluckow, M
中科院分区：
文献类型：
--
作者：
Kluckow, M
早产儿的过渡循环与足月儿显着不同。由于正常过渡循环过程的失败或延迟，早产儿特别面临低血压和低全身血流状态的风险。维持正常的组织氧合需要维持全身血流量和正常的血氧水平。这些生理参数的降低可能会导致器官损伤，从而导致脑室内出血和长期神经发育障碍等并发症。早产儿全身低血流量的识别和持续监测比年龄较大的儿童更具挑战性，并且儿科和成人重症监护环境中使用的一些评估技术不适用于新生儿环境。导管和心房的存在。分流使早产儿的心输出量测量出现问题，因此需要考虑其他测量全身血流量的新方法。对早产儿低血压和低心输出量状态的正确治疗首先需要了解潜在的病理生理学。皇冠版权所有 (c) 2005 由 Elsevier Ireland Ltd 出版。保留所有权利。
The transitional circulation of the preterm infant differs significantly from the term infant. The preterm infant is uniquely at risk of hypotension and Low systemic blood flow states due to failure or delay in the normal transitional circulation processes. The maintenance of normal tissue oxygenation requires maintenance of systemic blood flow and normal blood oxygen levels. Reduction in either of these physiological parameters may result in organ damage, leading to complications such as intraventricular haemorrhage and longer term neurodevelopmental disability. The identification and ongoing monitoring of low systemic blood flow in the preterm infant is more challenging than in older children and some of the assessment techniques used in paediatric and adult intensive care settings do not apply to the neonatal setting. The presence of ductal and atrial. shunts makes the measurement of cardiac output problematic in the preterm infant so other newer ways of measuring systemic blood flow need to be considered. The proper treatment of hypotensive and low cardiac output states in the preterm infant requires primarily an understanding of the underlying pathophysiology. Crown copyright (c) 2005 Published by Elsevier Ireland Ltd. All rights reserved.