Synergistic Activity of Colistin Combined With Auranofin Against Colistin-Resistant Gram-Negative Bacteria.
Synergistic Activity of Colistin Combined With Auranofin Against Colistin-Resistant Gram-Negative Bacteria.
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DOI：
10.3389/fmicb.2021.676414
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发表时间：
2021
影响因子：
5.2
通讯作者：
Cao B
中科院分区：
文献类型：
--
作者：
Feng X;Liu S;Wang Y;Zhang Y;Sun L;Li H;Wang C;Liu Y;Cao B
粘菌素耐药（Col-R）细菌正在稳步增加，并且非常难以治疗。迫切需要新的药物或疗法来治疗由这些病原体引起的感染。与多粘菌素等老药联合治疗，是恢复多粘菌素活性的重要途径。本研究旨在研究粘菌素与抗风湿药物金诺芬联合对Col-R革兰氏阴性菌的活性。棋盘格分析的结果表明，金诺芬与粘菌素协同对抗Col-R革兰氏阴性菌。时间杀灭试验显示粘菌素与金诺芬组合的显著协同抗微生物活性。电子显微镜显示，与单独使用每种药物相比，联合用药导致更多的细胞结构改变。金诺芬增强黏菌素在小鼠腹膜感染模型中的治疗效果。这些结果表明，粘菌素和金诺芬的组合可能是治疗Col-R革兰氏阴性细菌感染的潜在替代方案。
Colistin-resistant (Col-R) bacteria are steadily increasing, and are extremely difficult to treat. New drugs or therapies are urgently needed to treat infections caused by these pathogens. Combination therapy with colistin and other old drugs, is an important way to restore the activity of colistin. This study aimed to investigate the activity of colistin in combination with the anti-rheumatic drug auranofin against Col-R Gram-negative bacteria. The results of checkerboard analysis demonstrated that auranofin synergized with colistin against Col-R Gram-negative bacteria. Time-kill assays showed significant synergistic antimicrobial activity of colistin combined with auranofin. Electron microscopy revealed that the combination resulted in more cellular structural alterations compared to each drug alone. Auranofin enhanced the therapeutic effectiveness of colistin in mouse peritoneal infection models. These results suggested that the combination of colistin and auranofin might be a potential alternative for the treatment of Col-R Gram-negative bacterial infections.
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影响因子：
3
作者：
Roder, Christine;Thomson, Melanie J
通讯作者：
Thomson, Melanie J
影响因子：
5.3
作者：
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通讯作者：
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影响因子：
5.2
作者：
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通讯作者：
Rolain JM
DOI：
10.1073/pnas.1504022112
发表时间：
2015-04-07
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
56.3
作者：
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通讯作者：
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