Evaluation of serum oxidative and antioxidative status in patients with erectile dysfunction
Evaluation of serum oxidative and antioxidative status in patients with erectile dysfunction
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DOI：
10.1111/j.1439-0272.2011.01174.x
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发表时间：
2012-05
期刊：
影响因子：
2.4
通讯作者：
M. Aldemir;E. Okulu;S. Neşelioğlu;O. Erel;K. Ener;Ö. Kayıgil
中科院分区：
文献类型：
--
作者：
M. Aldemir;E. Okulu;S. Neşelioğlu;O. Erel;K. Ener;Ö. Kayıgil
我们评估并比较了勃起功能障碍（ED）患者和对照受试者的血清氧化和抗氧化参数。该研究包括 20 名患有 ED 至少 12 个月的已婚男性患者（第 1 组）和 20 名健康、性活跃、已婚且年龄匹配的志愿者志愿者（第 2 组）。比较第1组和第2组的血清平均总抗氧化能力（TAC）、总氧化状态（TOS）、对氧磷酶1（PON1）、芳基酯酶、总硫醇和氧化应激指数（OSI）。第 1 组和第 2 组的患者平均年龄分别为 47.9 ± 8.1 岁和 44.4 ± 10.6 岁。第 1 组和第 2 组的血清 TAC 水平分别为 1.7 ± 0.5 和 2.3 ± 0.3 (P = 0.002)。第 1 组和第 2 组的血清 TOS 水平分别为 21.8 ± 20.5 和 11.7 ± 2.2 (P = 0.035)。第 1 组和第 2 组的血清 PON1 水平分别为 69.8 ± 13.1 和 164.9 ± 56.5 (P < 0.001)。第 1 组和第 2 组的血清芳基酯酶水平分别为 336 ± 12 和 370.4 ± 47.9 (P = 0.003)。第 1 组和第 2 组的血清总硫醇水平分别为 733.1 ± 253 和 885.5 ± 95.3 (P = 0.016)。第 1 组和第 2 组的血清 OSI 分别为 0.14 ± 0.17 和 0.05 ± 0.11 (P = 0.021)。第 1 组的平均血小板计数显着较高 (P = 0.001)。发现血小板与氧化状态之间呈正相关，而血小板与抗氧化状态之间呈负相关。 ED 患者的氧化应激增加，而抗氧化参数降低。
We evaluated and compared serum oxidative and antioxidative parameters of patients with erectile dysfunction (ED) and control subjects. Twenty married male patients with ED for at least 12 months (Group 1) and 20 volunteer healthy, sexually active, married and age‐matched men (Group 2) were included in the study. Group 1 and 2 were compared concerning serum mean total antioxidant capacity (TAC), total oxidant status (TOS), paraoxonase1 (PON1), arylesterase, total thiol and oxidative stress index (OSI). Mean patient age was 47.9 ± 8.1 and 44.4 ± 10.6, respectively, in Group 1 and 2. Serum TAC levels were 1.7 ± 0.5 and 2.3 ± 0.3, respectively, in Group 1 and 2 (P = 0.002). Serum TOS levels were 21.8 ± 20.5 and 11.7 ± 2.2, respectively, in Group 1 and 2 (P = 0.035). Serum PON1 levels were 69.8 ± 13.1 and 164.9 ± 56.5, respectively, in Group 1 and 2 (P < 0.001). Serum arylesterase levels were 336 ± 12 and 370.4 ± 47.9, respectively, in Group 1 and 2 (P = 0.003). Serum total thiol levels were 733.1 ± 253 and 885.5 ± 95.3, respectively, in Group 1 and 2 (P = 0.016). Serum OSI was 0.14 ± 0.17 and 0.05 ± 0.11, respectively, in Group 1 and 2 (P = 0.021). Mean blood platelet count was significantly higher in Group 1 (P = 0.001). A positive correlation between platelets and oxidative state and a negative correlation between platelets and antioxidative state were found. Oxidative stress was detected to be increased, whereas antioxidative parameters were detected to be decreased in patients with ED.