Long-term moderate zinc supplementation increases exchangeable zinc pool masses in late-middle-aged men: the Zenith Study
Long-term moderate zinc supplementation increases exchangeable zinc pool masses in late-middle-aged men: the Zenith Study
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DOI：
10.1093/ajcn/82.1.103
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发表时间：
2005-07-01
影响因子：
7.1
通讯作者：
Coudray, C
中科院分区：
文献类型：
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作者：
Feillet-Coudray, C;Meunier, N;Coudray, C
背景：补充锌可能有益于健康。评估可交换锌池可能是评估锌状态的有用方法。目的：我们评估了长期补充 2 种中等剂量的锌对可交换锌池质量的影响。设计：三组健康的中年男性（每组 n = 16）在每日补充 0（安慰剂）、15 或 30 毫克锌 6 个月后参加了稳定同位素锌动力学研究。补充期结束时，每位受试者静脉注射0.89 mg Zn-70，并监测接下来10 d的血浆锌消失曲线。使用两种方法来确定可交换锌池的特征：1）正式的三室模型和2）快速可交换锌池（EZP）总质量的简化确定。结果：在安慰剂组中，3 个考虑池的可交换锌池质量如下：2.15、12.7 和 100.5 毫克锌。安慰剂组中快速交换的锌池质量为 143 毫克锌。无论采用何种方法确定这些库，锌的补充都会显着增加可交换锌库的质量。此外，这些数据证实，可交换锌池质量与总锌摄入量呈正相关，与受试者年龄呈负相关，与血浆锌浓度无关。结论：我们的数据表明，长期补充2种中等剂量的锌是增加中年男性可交换锌池质量的有效方法。
Background: Zinc supplementation may be beneficial for health. Assessing exchangeable zinc pools may be a useful approach to evaluate zinc status.Objective: We evaluated the effects of long-term supplementation with 2 moderate doses of zinc on the mass of exchangeable zinc pools.Design: Three groups of healthy, late-middle-aged men (n = 16 per group) participated in a stable-isotope zinc kinetic study after 6 mo of daily supplementation with 0 (placebo), 15, or 30 mg Zn. At the end of the supplementation period, each subject received an intravenous injection of 0.89 mg Zn-70, and the plasma zinc disappearance curve was monitored for the next 10d. Two approaches were used to determine the characteristics of the exchangeable zinc pools: 1) formal 3-compartmental modeling and 2) a simplified determination of the total mass of the rapidly exchangeable zinc pool (EZP). Results: In the placebo group, the exchangeable zinc pool masses for the 3 considered pools were as follows: 2.15, 12.7, and 100.5 mg Zn. The rapidly exchangeable zinc pool mass in the placebo group was 143 mg Zn. Zinc supplementation significantly increased the exchangeable zinc pool masses regardless of the approach used to determine these pools. In addition, these data confirm that exchangeable zinc pool masses correlate positively with total zinc intake and negatively with subject age and do not correlate with plasma zinc concentrations.Conclusion: Our data show that long-term supplementation with 2 moderate doses of zinc is an efficient way to increase exchangeable zinc pool masses in late-middle-aged men.